Rapid compensatory plasticity revealed by dynamic correlated activity in monkeys in vivo
Rapid compensatory plasticity revealed by dynamic correlated activity in monkeys in vivo
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DOI：
10.1038/s41593-023-01446-w
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发表时间：
2023-10
影响因子：
25
通讯作者：
Ariana R. Andrei;A. E. Akil;Natasha Kharas;R. Rosenbaum;K. Josić;Valentin Dragoi
中科院分区：
文献类型：
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作者：
Ariana R. Andrei;A. E. Akil;Natasha Kharas;R. Rosenbaum;K. Josić;Valentin Dragoi
为了产生自适应行为，神经网络必须在可塑性和稳定性之间取得平衡。计算工作表明，网络的稳定性需要可塑性机制被快速补偿过程所抵消。然而，这种过程还有待实验观察。在这里，我们证明了猴子视觉皮层（V1区）兴奋性神经元的重复光遗传学激活在清醒状态下，在几分钟的时间尺度上诱导了神经元相互作用强度的群体范围内的动态降低，但在休息期间没有。这种新形式的快速可塑性仅在相关结构中观察到，在整个试验中，放电率保持稳定。在平衡制度下运行的计算网络模型证实了实验结果，并揭示了抑制可塑性是负责响应于重复光刺激的相关活动减少。这些结果提供了第一个实验证据，快速稳态可塑性，主要是在清醒，稳定在强大的网络共激活神经元的相互作用。
To produce adaptive behavior, neural networks must balance between plasticity and stability. Computational work has demonstrated that network stability requires plasticity mechanisms to be counterbalanced by rapid compensatory processes. However, such processes have yet to be experimentally observed. Here we demonstrate that repeated optogenetic activation of excitatory neurons in monkey visual cortex (area V1) induces a population-wide dynamic reduction in the strength of neuronal interactions over the timescale of minutes during the awake state, but not during rest. This new form of rapid plasticity was observed only in the correlation structure, with firing rates remaining stable across trials. A computational network model operating in the balanced regime confirmed experimental findings and revealed that inhibitory plasticity is responsible for the decrease in correlated activity in response to repeated light stimulation. These results provide the first experimental evidence for rapid homeostatic plasticity that primarily operates during wakefulness, which stabilizes neuronal interactions during strong network co-activation.