Comparison of somatodendritic and axon terminal dopamine release in the ventral tegmental area and the nucleus accumbens
Comparison of somatodendritic and axon terminal dopamine release in the ventral tegmental area and the nucleus accumbens
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DOI：
10.1016/0306-4522(95)00396-7
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发表时间：
1996-02-01
期刊：
影响因子：
3.3
通讯作者：
Kruk, ZL
中科院分区：
文献类型：
--
作者：
Iravani, MM;Muscat, R;Kruk, ZL
在碳纤维微电极上使用快速循环伏安法来测量电刺激或化学刺激大鼠大脑切片（包括腹侧被盖区或伏隔核核心区）后多巴胺的释放。电或化学刺激产生与多巴胺对应的清晰伏安信号；腹侧被盖区释放的多巴胺少于伏隔核。与伏隔核相反，电刺激的腹侧被盖区多巴胺释放对河豚毒素不敏感，不受多巴胺摄取抑制剂、多巴胺D-2自受体激动剂或阻滞剂的影响。
Fast cyclic voltammetry at a carbon fibre microelectrode was used to measure dopamine release following electrical or chemical stimulation in rat brain slices incorporating either the ventral tegmental area or the core region of the nucleus accumbens. Electrical or chemical stimulation gave clear voltammetric signals which corresponded to dopamine; less dopamine was released in the ventral tegmental area than in the nucleus accumbens. In contrast to the nucleus accumbens, electrically stimulated dopamine release in the ventral tegmental area was not sensitive to tetrodotoxin, was not modified by the presence of dopamine uptake inhibitors, or agonist or blockers acting at dopamine D-2 autoreceptors.