Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol
Early nutritional supplementation in non-critically ill patients hospitalized for the 2019 novel coronavirus disease (COVID-19): Rationale and feasibility of a shared pragmatic protocol
复制标题
DOI：
10.1016/j.nut.2020.110835
复制
发表时间：
2020-06-01
期刊：
影响因子：
4.4
通讯作者：
Cereda, Emanuele
中科院分区：
文献类型：
--
作者：
Caccialanza, Riccardo;Laviano, Alessandro;Cereda, Emanuele
2019年12月开始，2019年新型冠状病毒病（COVID-19）在中国武汉引发了一场肺炎疫情，并在全球迅速蔓延。意大利是继中国之后受灾最严重的国家。考虑到营养不良肯定会影响COVID-19患者的有害后果，本文的目的是为COVID-19住院的非危重患者提供一种实用的早期营养补充方案。根据观察，大多数患者入院时伴有严重炎症和厌食症，导致食物摄入量急剧减少，并且相当大比例的患者出现呼吸衰竭，需要无创通气甚至持续气道正压通气。方法：为所有患者提供各种不同稠度的高热量密集饮食，以及易消化的食物和零食。入院时口服补充乳清蛋白以及静脉输注多种维生素、多种矿物质微量元素溶液。在25-羟基维生素D缺乏的情况下，胆骨化醇被及时补充。如果检测到营养风险，则提供两到三瓶蛋白质卡路里口服营养补充剂（ONS）。如果
Objectives: Beginning in December 2019, the 2019 novel coronavirus disease (COVID-19) has caused a pneumonia epidemic that began in Wuhan, China, and is rapidly spreading throughout the whole world. Italy is the hardest hit country after China. Considering the deleterious consequences of malnutrition, which certainly can affect patients with COVID-19, the aim of this article is to present a pragmatic protocol for early nutritional supplementation of non-critically ill patients hospitalized for COVID-19 disease. It is based on the observation that most patients present at admission with severe inflammation and anorexia leading to a drastic reduction of food intake, and that a substantial percentage develops respiratory failure requiring non-invasive ventilation or even continuous positive airway pressure.Methods: High-calorie dense diets in a variety of different consistencies with highly digestible foods and snacks are available for all patients. Oral supplementation of whey proteins as well as intravenous infusion of multivitamin, multimineral trace elements solutions are implemented at admission. In the presence of 25-hydroxyvitamin D deficit, cholecalciferol is promptly supplied. If nutritional risk is detected, two to three bottles of protein-calorie oral nutritional supplements (ONS) are provided. If