Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips
Mcp1p tracks microtubule plus ends to destabilize microtubules at cell tips
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DOI：
10.1016/j.febslet.2014.01.055
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发表时间：
2014-03
期刊：
影响因子：
3.5
通讯作者：
Fan Zheng;Tianpeng Li;M. Cheung;Viktoriya Syrovatkina;Chuanhai Fu
中科院分区：
文献类型：
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作者：
Fan Zheng;Tianpeng Li;M. Cheung;Viktoriya Syrovatkina;Chuanhai Fu
微管正末端受多种蛋白质的动态调节，以执行不同的细胞功能。在这里，我们表明，裂殖酵母裂殖酵母uncharacterized蛋白mcp 1 p是一个微管加端跟踪蛋白，它依赖于驱动蛋白-8 klp 6 p运输沿着微管对微管加端。在没有mcp 1 p的情况下，微管灾难和救援频率降低，导致微管+末端在细胞尖端的停留时间增加。因此，这些研究结果表明，mcp 1 p可能协同klp 6p在微管加端不稳定的微管。
Microtubule plus ends are dynamically regulated by a wide variety of proteins for performing diverse cellular functions. Here, we show that the fission yeastSchizosaccharomyces pombeuncharacterized protein mcp1p is a microtubule plus-end tracking protein which depends on the kinesin-8 klp6p for transporting along microtubules towards microtubule plus ends. In the absence of mcp1p, microtubule catastrophe and rescue frequencies decrease, leading to an increased dwell time of microtubule plus ends at cell tips. Thus, these findings suggest that mcp1p may synergize with klp6p at microtubule plus-ends to destabilize microtubules.