Clearance of edema fluid into cerebrospinal fluid. A mechanism for resolution of vasogenic brain edema.
Clearance of edema fluid into cerebrospinal fluid. A mechanism for resolution of vasogenic brain edema.
复制标题
清除水肿液进入脑脊液。
作者：
H. Reulen;M. Tsuyumu;A. Tack;A. Fenske;G. Prioleau
作者介绍了一项研究的结果，研究的决议血管源性脑水肿使用猫冷损伤。采用脑室-脑池灌注法观察RISA-I 131和蔗糖-C14标记的脑水肿液在脑室脑脊液中的分布情况。低压或高压灌注对水肿扩散的影响通过测量从受损皮质通过白色物质到心室室管膜的一系列组织块的水、钠、RISA-I 131和蔗糖-C14含量来确定。研究结果表明，增加水肿脑和CSF之间的流体静压梯度可增强水肿液进入脑室CSF的清除。低压心室灌注最终证明了这一点，与对照组相比，低压心室灌注显著减少了心室附近的水肿量。在低压灌注过程中，从组织中取出的液体中白蛋白、钠和钾的浓度表明，大流量是水肿通过细胞外间隙的主要方法。在高压灌注下，浓度曲线表明了水肿消退的替代机制，如扩散和重吸收到毛细血管中。
The authors present the results of an investigation studying the resolution of vasogenic brain edema using cold injury in cats. The appearance of RISA-I131 and sucrose-C14 lebeled edema fluid in the ventricular cerebrospinal fluid (CSF) was assessed by means of ventriculocisternal perfusion. The effect of low- or high-pressure perfusion on edema spread was determined by measuring the water, sodium, RISA-I131, and sucrose-C14 content of serial tissue blocks taken from the injured cortex through the white matter to the ventricular ependyma. The findings indicate that increasing the hydrostatic pressure gradient between edematous brain and CSF enhances the clearance of edema fluid into the ventricular CSF. This was conclusively demonstrated with low-pressure ventricular perfusion which markedly diminished the amount of edema close to the ventricles compared to the controls. The concentration of albumin, sodium, and potassium to the fluid removed from the tissue during low-pressure perfusion indicates that bulk flow was the primary method of edema movement through the extracellular space. With high-pressure perfusion the concentration profiles suggested alternative mechanisms of edema resolution, such as diffusion and reabsorption into capillaries.