Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy
Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy
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DOI：
10.1016/j.otohns.2004.12.014
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发表时间：
2005-06-01
影响因子：
3.4
通讯作者：
Wang, MB
中科院分区：
文献类型：
--
作者：
Lotempio, MM;Wang, KH;Wang, MB
目标。为了评估喉癌患者在接受放化疗或全喉切除加放射治疗后的生活质量问题。方法：49例有主要接受放化疗或全喉切除加术后放射治疗的喉癌患者完成了华盛顿大学生活质量量表第4版。患者是在学术大学头颈诊所自愿确定的。结果：49例患者均完成了上述仪器的制作，其中15例为一期放化疗，34例为全喉切除加放疗。在两个治疗组中，报告的领域没有显著差异的是外表、活动、娱乐、情绪、味道、唾液、焦虑和一般问题。然而，在疼痛、吞咽、咀嚼、言语和肩部功能方面，两组之间存在显著差异。喉切除术患者的语言功能障碍(P=0.001)和肩部功能障碍(P=0.018)，而放化疗组患者的疼痛、吞咽困难(P=0.061)和咀嚼困难(P=0.027)。结论：大多数喉癌患者，无论是接受放化疗还是全喉切除术，都报告了良好的功能结果和与健康相关的生活质量。疼痛、吞咽、咀嚼、唾液和肩部功能被记录为影响他们日常生活质量的重要因素。
OBJECTIVE. To evaluate quality of life issues in patients with laryngeal cancer after treatment with either chemoradiation or total laryngectomy and radiation therapy.METHODS: Forty-nine patients with a history of stage II-IV laryngeal squamous cell carcinoma treated primarily with either chemoradiation or by total laryngectomy with postoperative radiation completed the University of Washington Quality of Life instrument, version 4. Patients were identified on a volunteer basis in an academic university head and neck clinic setting. Each patient completed the above instrument, and statistical analysis was performed by Wilcoxon and x(2) tests.RESULTS: Instruments were completed by all 49 patients: 15 patients who underwent primary chemoradiation and 34 patients who underwent a total laryngectomy followed by radiation. Domains reported in both treatment groups without significant differences were appearance, activity, recreation, moods, taste, saliva, anxiety, and general questions. However, there were significant differences between the 2 groups in the domains of pain, swallowing, chewing, speech, and shoulder function. The laryngectomy patients reported greater impairment of speech (P = 0.001), and shoulder function (P = 0.018), whereas the chemoradiation patients suffered from greater pain, difficulty swallowing (P = 0.061), and problems chewing (P = 0.027).CONCLUSIONS: Most patients with laryngeal cancer, whether treated primarily with chemoradiation or total laryngectomy, reported excellent functional outcomes and health-related quality of life. Pain, swallowing, chewing, saliva, and shoulder function were recorded as significant factors affecting their daily quality of life.