MINIMAL CHANGE NEPHROTIC SYNDROME REVEALING SOLID TUMORS
MINIMAL CHANGE NEPHROTIC SYNDROME REVEALING SOLID TUMORS
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DOI：
10.1159/000186877
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发表时间：
1992-06-01
期刊：
影响因子：
2.5
通讯作者：
RAINFRAY, M
中科院分区：
文献类型：
--
作者：
MEYRIER, A;DELAHOUSSE, M;RAINFRAY, M
2例肾病综合征患者中，1例为小细胞肺癌，合并ADH分泌异常综合征。另一个是乳腺癌伴淋巴结和骨转移。在这两种情况下，肾活检显示无免疫复合物沉积的微小病变疾病。只有14例报告的副肿瘤性脂质肾病并发实体瘤。这些病例导致了对肿瘤细胞基因产物诱导蛋白尿和淋巴细胞分泌针对肿瘤本身的淋巴因子各自作用的讨论。成人微小病变型肾病综合征的病因可能与癌症有关。
In 2 patients with the nephrotic syndrome, unsuspected solid tumors were found, One was a small cell lung carcinoma, accompanied with the syndrome of inappropriate ADH secretion. The other was a cancer of the breast with lymph node and bone metastases. In both, renal biopsy showed minimal change disease without immune complex deposits. There are only 14 other reported cases of paraneoplastic lipoid nephrosis complicating solid tumors. Such cases lead to the discussion on the respective roles of tumor cell gene product(s) inducing proteinuria and of lymphokine secretion by lymphocytes directed against the tumor itself. Cancer should be considered as a possible etiology of the minimal change nephrotic syndrome in the adult.