Prevalence of and Factors Associated with Human Cysticercosis in 60 Villages in Three Provinces of Burkina Faso
Prevalence of and Factors Associated with Human Cysticercosis in 60 Villages in Three Provinces of Burkina Faso
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DOI：
10.1371/journal.pntd.0004248
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发表时间：
2015-11-01
影响因子：
3.8
通讯作者：
Ganaba, Rasmane
中科院分区：
文献类型：
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作者：
Carabin, Helene;Millogo, Athanase;Ganaba, Rasmane
背景猪带绦虫是一种在人与猪之间传播的人畜共患病，被认为是撒哈拉以南非洲地区的一种新出现的感染，但与人类幼虫阶段感染（囊尾蚴病）相关的个人和社区因素尚不清楚。本研究旨在评估布基纳法索三个省 60 个村庄中个人层面和村庄层面因素与当前人类囊尾蚴病的关联程度。方法/主要发现使用了 2011 年 2 月至 2012 年 1 月期间从一项大型社区随机对照试验中收集的基线横断面数据。共有 3609 人提供了血清样本来评估当前的囊尾蚴病感染情况。使用贝叶斯分层逻辑模型估计个人和村级因素与当前囊尾蚴病感染率之间的关联。所有回归系数均使用扩散先验。目前囊尾蚴病的患病率在各省和村庄之间存在差异，从0%到11.5%不等。获得的结果表明，年龄的增加、男性的增加、食用猪肉、流浪猪的比例增加以及村级土壤中沙子的比例与较高的感染流行率有关。此外，在另一个村庄市场消费猪肉当前感染的患病率增加最高。拥有厕所、居住在财富五分位数较高的家庭以及村庄一级测量的土壤 pH 值较高，可降低囊尾蚴病的患病几率。结论/意义这是第一项大型研究，旨在检验个人、家庭和村庄层面测量的变量与人类囊尾蚴病患病几率之间的关系。与人、猪和环境相关的因素非常重要，这进一步支持了采用“同一个健康”方法来控制囊尾蚴病感染的必要性。
BackgroundTaenia solium, a zoonotic infection transmitted between humans and pigs, is considered an emerging infection in Sub-Saharan Africa, yet individual and community-level factors associated with the human infection with the larval stages (cysticercosis) are not well understood. This study aims to estimate the magnitude of association of individual-level and village-level factors with current human cysticercosis in 60 villages located in three Provinces of Burkina Faso.Methodology/Principal FindingsBaseline cross-sectional data collected between February 2011 and January 2012 from a large community randomized-control trial were used. A total of 3609 individuals provided serum samples to assess current infection with cysticercosis. The association between individual and village-level factors and the prevalence of current infection with cysticercosis was estimated using Bayesian hierarchical logistic models. Diffuse priors were used for all regression coefficients. The prevalence of current cysticercosis varied across provinces and villages ranging from 0% to 11.5%. The results obtained suggest that increased age, being male and consuming pork as well as a larger proportion of roaming pigs and percentage of sand in the soil measured at the village level were associated with higher prevalences of infection. Furthermore, consuming pork at another village market had the highest increased prevalence odds of current infection. Having access to a latrine, living in a household with higher wealth quintiles and a higher soil pH measured at the village level decreased the prevalence odds of cysticercosis.Conclusions/SignificanceThis is the first large-scale study to examine the association between variables measured at the individual-, household-, and village-level and the prevalence odds of cysticercosis in humans. Factors linked to people, pigs, and the environment were of importance, which further supports the need for a One Health approach to control cysticercosis infection.