Haematological Changes Associated with the McLeod Phenotype of the Kell Blood Group System
Haematological Changes Associated with the McLeod Phenotype of the Kell Blood Group System
复制标题
与凯尔血型系统麦克劳德表型相关的血液学变化
DOI：
--
复制
发表时间：
1977
影响因子：
6.5
通讯作者：
W. Galey
中科院分区：
文献类型：
--
作者：
B. Wimer;W. Marsh;H. Taswell;W. Galey
McLeod表型作为X连锁特征遗传。红细胞在Kell血型中具有弱的抗原性，并且缺乏Kx，Kx是一种似乎是Kell抗原的适当生物合成所必需的类似蛋白质的物质。建立正常细胞形态也需要Kx抗原。缺乏Kx抗原导致膜异常，其中最突出的特征是棘红细胞增多症和代偿性溶血状态。
The McLeod phenotype is inherited as an X‐linked characteristic. The red cells have weak antigenicity in the Kell blood group and lack Kx, a precursorlike substance that appears to be necessary for proper biosynthesis of Kell antigens. Kx antigen is also required for establishment of normal cell morphology. Absence of Kx antigen causes a membrane abnormality, in which the most prominent feature is acanthocytosis, and a compensated haemolytic state.