Lifetime eco-nanotoxicology in an adult organism: where and when is the invertebrate C. elegans vulnerable?
Lifetime eco-nanotoxicology in an adult organism: where and when is the invertebrate C. elegans vulnerable?
复制标题
DOI：
10.1039/c7en01061c
复制
发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
A. Mikecz
中科院分区：
文献类型：
--
作者：
A. Mikecz
本文综述了线虫线虫秀丽隐杆线虫的纳米毒理学。特别强调的是野生C. elegans与工程纳米材料的模拟环境汇相关。概述了关于第一次相遇的各自假设，并将蠕虫确定为纳米颗粒的相关靶生物。在实验室C。秀丽隐杆线虫代表了一种在遗传和实验上都能接受的动物模型，其生命周期由几个幼虫阶段组成，随后是仅2-3周的成虫寿命。后者可以长期观察纳米颗粒对年轻，中年和老年蠕虫的影响。一幅图片出现，某些纳米材料诱导过早衰老过程，从而减少健康的跨度和寿命的C。优雅蠕虫的神经系统变成了一个突出的靶器官，表现出神经肌肉缺陷，其中包括表现在单个神经元的神经变性，结合改变运动，减少繁殖力和嗅觉受损。值得注意的是，特定的脆弱性发生在不同年龄的成年C。优雅野生C. elegans进行了讨论，是系统生物学为基础的战略，以确定共同的途径纳米粒子生物相互作用从蠕虫到男人。
This review addresses nanotoxicology in the nematode roundworm Caenorhabditis elegans. Special emphasis is on the natural habitats of wild C. elegans in correlation with modeled environmental sinks of engineered nanomaterials. Respective hypotheses about a first encounter are outlined and identify the worm as a relevant target organism of nanoparticles. In the laboratory C. elegans represents a genetically and experimentally amenable animal model that leads a boom life cycle consisting of several larval stages followed by an adult life span of only 2–3 weeks. The latter enables long-term observation of nanoparticle effects in young, middle-aged and old worms. A picture emerges that certain nanomaterials induce premature aging processes, thereby reducing the health span and longevity of C. elegans. The neural system of the worm turns out as a prominent target organ showing neuromuscular defects that among others manifest in neurodegeneration of single neurons in combination with altered locomotion, reduced fecundity and impaired olfaction. Notably, specific vulnerabilities occur at distinct ages of adult C. elegans. Conceivable consequences of neural defects for wild C. elegans are discussed, as are system biology-based strategies to identify common pathways of nanoparticle–bio-interactions from worm to men.