Diamond coated artificial cardiovascular devices.
Diamond coated artificial cardiovascular devices.
复制标题
金刚石涂层人工心血管装置。
DOI：
10.1016/j.surfcoat.2016.06.030
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发表时间：
2016
影响因子：
5.4
通讯作者：
Carlisle,John
中科院分区：
文献类型：
--
作者：
Zeng,Hongjun;Jarvik,Robert;Catausan,Grace;Moldovan,Nicolaie;Carlisle,John
超微晶金刚石（UNCD®）是一种非常光滑，低成本的金刚石涂层，成功开发用于抗血栓形成应用，要求高生物相容性，低磨损，低摩擦和化学惰性。Jarvik 2000心室辅助装置（VAD）中使用的衬底材料，碳化硅和钛合金，为UNCD集成提供了极好的衬底匹配。本文讨论了医疗质量UNCD薄膜的开发，以显着提高关于UNCD薄膜缺陷机制的知识库，减少或消除薄膜中已知的磨损缺陷，并彻底表征和测试薄膜以及组装的UNCD涂层vad。通过减少缺陷和播种实验，提高薄膜附着力和涂层质量，筛选出最佳候选沉积方法，用于Jarvik Heart VAD零件的涂层和装配。涂层和组装的设备已经在Jarvik Heart进行了机械和血液模拟流体动力学测试，以全面验证新的涂层技术。UNCD界面结合了无与伦比的耐用性和抗血栓性。
Ultrananocrystalline diamond (UNCD®), an extremely smooth, low cost diamond coating was successfully developed herein for antithrombogenic application which requires high biocompatibility, low wear, low friction, and chemical inertness. The substrate materials utilized in the Jarvik 2000 ventricular assist device (VAD), silicon carbide and titanium alloy, provide an excellent substrate match for UNCD integration. The paper addresses the development of medical-quality UNCD films to significantly improve the knowledge base regarding the defect mechanisms of UNCD films, to reduce or eliminate known wear-inducing imperfections in the film, and to thoroughly characterize and test the films as well as assembled UNCD-coated VADs. After the defect reduction and seeding experiments to improve film adhesion and coating quality, the best candidate deposition method has been down-selected for coating and assembly of VAD parts from Jarvik Heart. The coated and assembled devices have been tested with mechanical and blood-simulating fluid hydrodynamic testing at Jarvik Heart for full verification of the new coating technology. UNCD interface takes advantage of combining unmatched durability and antithrombogenicity.