Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis.
Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis.
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DOI：
10.3390/ijms22041659
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发表时间：
2021-02-07
影响因子：
5.6
通讯作者：
Suzuki YJ
中科院分区：
文献类型：
--
作者：
Seeherman S;Suzuki YJ
目前流行的2019年冠状病毒病(新冠肺炎)是由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的。虽然这种呼吸道病毒只会在年轻健康的人中引起轻微的症状，但老年人和那些患有系统性高血压等心血管疾病的人容易出现严重的情况，可能是致命的。SARS-CoV-2感染还与心血管疾病的发生率增加有关，如心肌损伤、急性冠脉综合征和血栓栓塞症。因此，了解这种病毒对心血管系统影响的机制应该有助于制定治疗策略，以减少与SARS-CoV-2感染相关的死亡率和发病率。由于这种病毒会导致患有心血管并发症的老年人出现严重和致命的情况，针对特定人群的有效治疗可能有助于结束这一大流行。在这篇综述文章中，描述了各种病毒-包括其他冠状病毒、流感、登革热和人类免疫缺陷病毒-对心血管系统的影响，以帮助提供与SARS-CoV-2感染和新冠肺炎相关的病理分子机制。其目标是提供与心血管病理有关的其他病毒感染生物学的机械性信息，以开发有效预防和/或治疗SARS-CoV-2和新冠肺炎的急性和长期后果的改进疫苗和治疗剂。
The current pandemic of coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While this respiratory virus only causes mild symptoms in younger healthy individuals, elderly people and those with cardiovascular diseases such as systemic hypertension are susceptible to developing severe conditions that can be fatal. SARS-CoV-2 infection is also associated with an increased incidence of cardiovascular diseases such as myocardial injury, acute coronary syndrome, and thromboembolism. Understanding the mechanisms of the effects of this virus on the cardiovascular system should thus help develop therapeutic strategies to reduce the mortality and morbidity associated with SARS-CoV-2 infection. Since this virus causes severe and fatal conditions in older individuals with cardiovascular comorbidities, effective therapies targeting specific populations will likely contribute to ending this pandemic. In this review article, the effects of various viruses—including other coronaviruses, influenza, dengue, and human immunodeficiency virus—on the cardiovascular system are described to help provide molecular mechanisms of pathologies associated with SARS-CoV-2 infection and COVID-19. The goal is to provide mechanistic information from the biology of other viral infections in relation to cardiovascular pathologies for the purpose of developing improved vaccines and therapeutic agents effective in preventing and/or treating the acute and long-term consequences of SARS-CoV-2 and COVID-19.
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DOI：
10.4269/ajtmh.2012.11-0692
发表时间：
2012-10-01
影响因子：
3.3
作者：
Goncalves da Costa, Paulo Sergio;Ribeiro, Geyza Machado;Campos, Lenilton da Costa
通讯作者：
Campos, Lenilton da Costa
影响因子：
17.1
作者：
Beatty, P. Robert;Puerta-Guardo, Henry;Harris, Eva
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Harris, Eva
影响因子：
4.8
作者：
Cheung YP;Mastrullo V;Maselli D;Butsabong T;Madeddu P;Maringer K;Campagnolo P
通讯作者：
Campagnolo P
影响因子：
7.3
作者：
Hamming, I;Timens, W;van Goor, H
通讯作者：
van Goor, H
影响因子：
64.8
作者：
Crackower, MA;Sarao, R;Penninger, JM
通讯作者：
Penninger, JM