EXPLORING THE ANTITUMOR EFFECT OF VIRUS IN MALIGNANT GLIOMA.
EXPLORING THE ANTITUMOR EFFECT OF VIRUS IN MALIGNANT GLIOMA.
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DOI：
10.1358/dof.2015.040.11.2383070
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发表时间：
2015
影响因子：
0.2
通讯作者：
Rabkin SD
中科院分区：
文献类型：
--
作者：
Saha D;Ahmed SS;Rabkin SD
恶性胶质瘤是最常见的原发恶性脑肿瘤，目前尚无有效的治疗方法。目前的常规治疗(手术切除、放射治疗、替莫唑胺(TMZ)和贝伐单抗应用)通常不能根除肿瘤，从而导致耐药肿瘤的复发。因此，需要新的方法来改善治疗结果。溶瘤病毒(OV)是治疗恶性胶质瘤等侵袭性癌症的一种更有效的候选策略，因为OV具有天然的偏好或已被基因工程有选择地在癌细胞中复制和杀伤。OVS已被用于治疗恶性胶质瘤的大量临床前研究，大量使用OVS的临床试验已经完成或正在进行，这些试验已经证明是安全的，并提供了有效的抗胶质瘤活性的迹象。在这篇综述中，我们将重点介绍已用于治疗恶性胶质瘤的临床试验中的OV(单纯疱疹病毒、腺病毒、细小病毒、呼肠孤病毒、脊髓灰质炎病毒、新城疫病毒、麻疹病毒和逆转录病毒)和临床前检查过的OV(水泡性口炎病毒和粘液瘤病毒)，并描述这些药物的使用情况。
Malignant gliomas are the most common type of primary malignant brain tumor with no effective treatments. Current conventional therapies (surgical resection, radiation therapy, temozolomide (TMZ), and bevacizumab administration) typically fail to eradicate the tumors resulting in the recurrence of treatment-resistant tumors. Therefore, novel approaches are needed to improve therapeutic outcomes. Oncolytic viruses (OVs) are excellent candidates as a more effective therapeutic strategy for aggressive cancers like malignant gliomas since OVs have a natural preference or have been genetically engineered to selectively replicate in and kill cancer cells. OVs have been used in numerous preclinical studies in malignant glioma, and a large number of clinical trials using OVs have been completed or are underway that have demonstrated safety, as well as provided indications of effective antiglioma activity. In this review, we will focus on those OVs that have been used in clinical trials for the treatment of malignant gliomas (herpes simplex virus, adenovirus, parvovirus, reovirus, poliovirus, Newcastle disease virus, measles virus, and retrovirus) and OVs examined preclinically (vesicular stomatitis virus and myxoma virus), and describe how these agents are being used.