A Paradigm Change in Functional Brain Mapping: Suppressing the Thermal Noise in fMRI

A Paradigm Change in Functional Brain Mapping: Suppressing the Thermal Noise in fMRI
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功能性脑图谱的范式变化:抑制功能磁共振成像中的热噪声

DOI:
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发表时间:
2020
期刊:
影响因子:
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通讯作者:
K. Uğurbil
K. Uğurbil
中科院分区:
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文献类型:
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作者:
L. Vizioli;S. Moeller;Logan T Dowdle;M. Akçakaya;Federico De Martino;E. Yacoub;K. Uğurbil

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功能磁共振成像(fMRI)已成为研究人类大脑的最有力的工具之一。然而,几乎所有的fMRI研究都有相对较差的信噪比(SNR)。我们介绍了一种新的功能磁共振去噪技术,去除噪声是无法区分的零均值高斯分布噪声。热噪声属于这一类,是fMRI中的主要噪声源,特别是但不限于高空间和/或时间分辨率。使用7特斯拉的高分辨率数据,我们展示了显着的改善,在时间信噪比,刺激诱导的信号变化的检测,和功能图,而刺激诱导的信号变化幅度,图像空间分辨率,和功能点扩散函数不变。我们还提供了补充数据,证明该方法同样适用于超毫米分辨率3-和7-特斯拉的功能磁共振成像数据,不同的皮层区域,刺激/任务范例,和采集策略。所提出的去噪方法有望对fMRI研究大脑的范围和应用产生变革性的影响。
Functional magnetic resonance imaging (fMRI) has become one of the most powerful tools for investigating the human brain. However, virtually all fMRI studies have relatively poor signal-to-noise ratio (SNR). We introduce a novel fMRI denoising technique, which removes noise that is indistinguishable from zero-mean Gaussian-distributed noise. Thermal noise, falling in this category, is a major noise source in fMRI, particularly, but not exclusively, at high spatial and/or temporal resolutions. Using 7-Tesla high-resolution data, we demonstrate remarkable improvements in temporal-SNR, the detection of stimulus-induced signal changes, and functional maps, while leaving stimulus-induced signal change amplitudes, image spatial resolution, and functional point-spread-function unaltered. We also provide supplementary data demonstrating that the method is equally applicable to supra-millimeter resolution 3- and 7-Tesla fMRI data, different cortical regions, stimulation/task paradigms, and acquisition strategies. The proposed denoising approach is expected to have a transformative impact on the scope and applications of fMRI to study the brain.
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