Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.
Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma.
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DOI：
10.1002/adma.201604932
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Stevens MM
中科院分区：
文献类型：
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作者：
Chandrawati R;Chang JYH;Reina-Torres E;Jumeaux C;Sherwood JM;Stamer WD;Zelikin AN;Overby DR;Stevens MM
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
