Decrease in milk and blood dioxin levels over two years in a mother nursing twins: estimates of decreased maternal and increased infant dioxin body burden from nursing.
Decrease in milk and blood dioxin levels over two years in a mother nursing twins: estimates of decreased maternal and increased infant dioxin body burden from nursing.
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哺乳双胞胎的母亲两年内乳汁和血液二恶英水平下降：估计母乳和婴儿二恶英身体负担因哺乳而减少。
DOI：
10.1016/0045-6535(95)00248-0
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发表时间：
1996
期刊：
影响因子：
8.8
通讯作者：
H. Kessler
中科院分区：
文献类型：
--
作者：
A. Schecter;O. Päpke;A. Lis;M. Ball;Jake Ryan;James R. Olson;Lingjun Li;H. Kessler
本研究旨在探讨母乳喂养及其减少母体二恶英负担的问题。哺乳也是婴儿接触二恶英的一个来源。这项研究扩展了我们以前的努力，调查哺乳母亲的牛奶和血液二恶英水平。我们报告了双胞胎哺乳前和哺乳后两年内牛奶（M）和血液（B）中的多氯二苯并二恶英（PCDD）和多氯二苯并呋喃（PCDF）二恶英毒性当量（TEQs）分别为16.9 ppt（M）、14.9 ppt（B）和3.1 ppt（M）和4.9 ppt（B）。1992年和1994年，母乳与哺乳期母亲最初和哺乳期母亲两年后的全血相比，测得的同源物比率分别为0.36至8.40和0.17至1.0。使用1992年2月采集的样本，母亲的体内负荷最初计算为来自乳汁的329纳克毒性当量和来自血液的291纳克毒性当量，使用1994年12月采集的样本，母亲的体内负荷降至来自乳汁的60.1纳克毒性当量和来自血液的96纳克毒性当量。我们计算出母亲通过母乳喂养排出的二恶英TEQ为269 ng TEQ，这与双胞胎两年来估计的二恶英总摄入量303 ng TEQ相似。在过去两年，每对双胞胎平均每天从护理中摄入的二恶英为66皮克毒性当量/千克体重/天。
This study addresses the issue of breast-feeding and its reduction of maternal dioxin body burden. Nursing is also a source of infant dioxin exposure. This study extends our previous efforts to investigate a nursing mother's milk and blood dioxin levels. We report polychlorinated dibenzo-p-dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) dioxin toxic equivalents (TEQs) in milk (M) and blood (B) both before and also after two years of nursing twins to be 16.9 ppt (M), 14.9 ppt (B), and 3.1 ppt (M) and 4.9 ppt (B), respectively. The ratios of measured congeners comparing milk to whole blood from a nursing mother taken initially and after two years of nursing vary from 0.36 to 8.40 in 1992 and 0.17 to 1.0 in 1994. The mother's body burden was initially calculated to be 329 ng TEQ from milk levels and 291 ng TEQ from blood levels using samples taken in February 1992 and decreased to 60.1 ng TEQ from milk and 96 ng TEQ from measured blood using samples collected in December 1994. We calculate that the excretion of dioxin TEQ by the mother through breast-feeding is 269 ng TEQ, which is similar to the 303 ng TEQ estimated total dioxin intake by the twins over two years. The average daily dioxin intake from nursing is 66 pg TEQ/kg-BW/day for each twin over the two years.