IMMUNOCYTOCHEMICAL CHARACTERIZATION OF THE UNUSUAL LARGE GRANULAR LYMPHOCYTES IN HUMAN-ENDOMETRIUM THROUGHOUT THE MENSTRUAL-CYCLE
IMMUNOCYTOCHEMICAL CHARACTERIZATION OF THE UNUSUAL LARGE GRANULAR LYMPHOCYTES IN HUMAN-ENDOMETRIUM THROUGHOUT THE MENSTRUAL-CYCLE
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DOI：
10.1016/0198-8859(89)90060-8
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发表时间：
1989-03-01
期刊：
影响因子：
2.7
通讯作者：
LOKE, YW
中科院分区：
文献类型：
--
作者：
KING, A;WELLINGS, V;LOKE, YW
使用一组针对子宫内膜冰冻切片上的自然杀伤细胞、T细胞、B细胞和巨噬细胞的单抗对月经周期的所有阶段的白细胞进行了研究。在植入时(分泌中期)，大多数白细胞为Leu19+、CD16-、Leu7-、CD2+、CD3-、CD5-、CD7-和HLADR-，形态为大颗粒淋巴细胞。这些细胞的数量在分泌中期明显增加。这些细胞表现出与蜕膜中发现的相似的表型特征。因此，这些发现表明，这些大颗粒淋巴细胞向子宫的募集是受激素控制的，而不是对侵入的滋养细胞存在的局部反应。
Leukocyte populations were studied at all stages of the menstrual cycle using a panel of monoclonal antibodies to natural killer cells, T cells, B cells, and macrophages on frozen sections of endometrium. At the time of implantation (mid-secretory phase) the majority of leukocytes appear to be Leu19+, CD16-, Leu7-, CD2+, CD3-, CD5-, Cd7-, and HLA DR- with the morphology of large granular lymphocytes. The numbers of these cells showed a marked increase in the mid-secretory phase. These cells exhibited similar phenotypic characteristics to those found in decidua. These findings, therefore, suggest that the recruitment of these large granular lymphocytes to the uterus is under hormonal control and is not a local response to the presence of invading trophoblast.