Cortical auditory dysfunction in children with oral clefts:: relation with cleft type
Cortical auditory dysfunction in children with oral clefts:: relation with cleft type
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DOI：
10.1016/s1388-2457(99)00152-2
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发表时间：
1999-11-01
影响因子：
4.7
通讯作者：
Näätänen, R
中科院分区：
文献类型：
--
作者：
Ceponiene, R;Hukki, J;Näätänen, R
目的：高达46%的唇腭裂患者患有语言学习障碍。这些残疾的程度根据唇裂的类型而有所不同。认知功能障碍的发病机制及其与裂型的关系尚不清楚。我们调查的持久性听觉短期记忆（STM），这是隐含的语言特异性的知觉与分裂的儿童，分组使用精细分级的裂缝classification.Methods：皮层诱发电位记录在78名儿童与非综合征性口裂，并在32个健康的同龄人。一个失配负波（MMN）的潜在指标的听觉输入的变化的前注意检测得到的音调的声音。结果：在最慢刺激频率下，腭裂儿童MMN波幅较正常儿童明显降低（P <0.00065），而在最慢刺激频率下，腭裂儿童MMN波幅较正常儿童明显降低（P < 0.00065）。只有唇裂儿童与对照组没有显著差异。在孤立性腭裂中，腭裂越靠后，MMN的波幅越小。最小振幅的MMN中获得的子组完全单侧唇腭裂。结论：MMN振幅降低，发现在腭裂儿童，意味着缺乏听觉STM痕迹的维护。这种功能障碍可能会导致他们的语言和学习障碍。MMN减少与更短/更多的后裂表明，听觉皮层功能的差异是裂型malcogniton协会的潜在机制之一。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Objective: Up to 46% of individuals with oral clefts suffer from language-learning disabilities. The degree of these disabilities varies according to cleft type. The pathogenesis of cognitive malfunctioning or its relationship with cleft type is not known. We investigated persistence of auditory short-term memory (STM) that is implicitly involved in language-specific perception in children with clefts, grouped using fine-graded cleft classification.Methods: Cortical evoked potentials were recorded in 78 children with non-syndromic oral clefts and in 32 healthy peers. A mismatch negativity (MMN) potential that indexes preattentive detection of change in auditory input was obtained in response to tone sounds. In order to test durability of short-term memory traces, sounds were presented with three stimulation rates.Results: With slowest stimulation, MMN amplitudes were reduced in cleft children as compared to the healthy peers (P < 0.00065). Only cleft-lip children did not significantly differ from controls. Among isolated palatal clefts, the more posteriorly delimited the cleft was, the smaller was the amplitude of MMN. MMNs of smallest amplitudes were obtained in the subgroup of complete unilateral cleft of lip and palate.Conclusions: Reduced MMN amplitudes, found in cleft children, imply deficiency in auditory STM trace maintenance. This dysfunction is likely to contribute to their language and learning disabilities. The MMN diminution with shorter/more posterior clefts suggests that differences in auditory cortex function are one of the underlying mechanisms of the cleft type-malcogniton association. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.