MODULATION OF CARDIAC AUTONOMIC ACTIVITY DURING AND IMMEDIATELY AFTER EXERCISE
MODULATION OF CARDIAC AUTONOMIC ACTIVITY DURING AND IMMEDIATELY AFTER EXERCISE
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DOI：
10.1152/ajpheart.1989.256.1.h132
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发表时间：
1989-01-01
影响因子：
--
通讯作者：
COLUCCI, WS
中科院分区：
文献类型：
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作者：
ARAI, Y;SAUL, JP;COLUCCI, WS
心率在0.03 Hz以上的波动反映了窦房结活动的自主调节。为了评估运动过程中和运动后即刻自主神经活动的动力学，我们测定了43例无已知心脏病的正常受试者、8例严重充血性心力衰竭患者和6例心脏移植后患者在自行车功率计上进行分级负荷运动之前、期间和之后的心率和呼吸波动的功率谱。运动前，正常受试者在高（0.15-0.80 Hz）和低（0.03-0.15 Hz）频率下的心率波动（频谱功率）显著高于心力衰竭或移植患者，但两组心脏病患者之间没有差异。在运动过程中，正常人在所有频率下的心率功率迅速和进行性下降，直到峰值运动时，它与其他两组没有差异。在恢复期间，正常受试者的心率功率增加，但仍显着低于基线。研究结果表明，心力衰竭患者和心脏移植后心率的自主调节明显减少，并支持在正常受试者恢复期间逐渐增加的运动过程中逐渐撤回迷走神经活动。
Fluctuations in heart rate above 0.03 Hz reflect autonomic modulation of sinoatrial node activity. To assess the dynamics of autonomic nervous activity during and immediately after exercise, we determined the power spectrum of heart rate and respiratory fluctuations in 43 normal subjects without known cardiac disease, 8 patients with severe congestive heart failure, and 6 patients status-post cardiac transplantation before, during and after graded-work load exercise on a cycle ergometer. Before exercise, heart rate fluctuations (spectral power) at both high (0.15-0.80 Hz) and low (0.03-0.15 Hz) frequencies were significantly higher in normal subjects than in either heart failure or transplant patients but were not different between the two groups with heart disease. During exercise, heart rate power at all frequencies rapidly and progressively decreased in normal subjects, until at peak exercise it was not different from the other two groups. During recovery, heart rate power increased in normal subjects but remained significantly below base line. The findings demonstrate a marked reduction of autonomic modulation of heart rate in patients with heart failure and after cardiac transplant and support a progressive withdrawal of vagal activity during exercise with a gradual increase during recovery in normal subjects.