Growth Charts for Non-Growth Hormone Treated Prader-Willi Syndrome
Growth Charts for Non-Growth Hormone Treated Prader-Willi Syndrome
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DOI：
10.1542/peds.2014-1711
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发表时间：
2015-01-01
期刊：
影响因子：
8
通讯作者：
Driscoll, Daniel J.
中科院分区：
文献类型：
--
作者：
Butler, Merlin G.;Lee, Jaehoon;Driscoll, Daniel J.
目的：本研究的目的是生成和报告3至18岁之间的患有Prader-Willi综合征（PWS）的非生长激素治疗的美国白色男性和女性受试者的体重、身高、头围和BMI的标准化生长曲线，并制定标准化生长图表。根据标准方法，从120名未经生长激素治疗的3至18岁患有PWS的白色受试者（63名男性和57名女性）中获得人体测量指标（N = 133）。通过使用LMS方法对PWS受试者的体重、身高、头围和BMI沿着来自国家和国际生长数据的规范性第3、50和97个月的标准化生长曲线进行了开发。LMS平滑程序使用三个参数总结了每个年龄的人体测量变量的分布：Box-Cox变换的功率lambda（L），中位数mu（M）和变异系数delta（S）。体重身高头围从120名非生长激素治疗的白色男性和女性PWS美国受试者中开发了代表7个百分位数范围的BMI标准化生长图表（年龄范围：3-18岁）和规范性的第三，第50，和第97次从国家和国际data.CONCLUSIONS：我们鼓励使用症状特异性生长标准，检查和评估PWS受试者时，监测生长模式和确定营养和肥胖状况。这些变量可能受到文化、个人医疗保健、饮食干预和体育活动计划的影响。
OBJECTIVE: The goal of this study was to generate and report standardized growth curves for weight, height, head circumference, and BMI for non-growth hormone-treated white male and female US subjects with Prader-Willi syndrome (PWS) between 3 and 18 years of age and develop standardized growth charts.METHODS: Anthropometric measures (N = 133) were obtained according to standard methods from 120 non-growth hormone-treated white subjects (63 males and 57 females) with PWS between 3 and 18 years of age. Standardized growth curves were developed for the third, 10th, 25th, 50th, 75th, 90th, and 97th percentiles by using the LMS method for weight, height, head circumference, and BMI for PWS subjects along with the normative third, 50th, and 97th percentiles from national and international growth data. The LMS smoothing procedure summarized the distribution of the anthropometric variables at each age using three parameters: power of the Box-Cox transformation lambda (L), median mu (M) and coefficient of variation delta (S).RESULTS: Weight, height, head circumference, and BMI standardized growth charts representing 7 percentile ranges were developed from 120 non-growth hormone-treated white male and female US subjects with PWS (age range: 3-18 years) and normative third, 50th, and 97th percentiles from national and international data.CONCLUSIONS: We encourage the use of syndrome-specific growth standards to examine and evaluate subjects with PWS when monitoring growth patterns and determining nutritional and obesity status. These variables can be influenced by culture, individual medical care, diet intervention, and physical activity plans.