Interplay of estrogen receptors and FOXA factors in the liver cancer.
Interplay of estrogen receptors and FOXA factors in the liver cancer.
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DOI：
10.1016/j.mce.2015.01.043
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发表时间：
2015-12-15
影响因子：
4.1
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Zhao Y;Li Z
肝癌是人类第五大常见癌症，男性占主导地位。从啮齿类动物到人类，肝癌的性二态性是保守的，这是在20世纪30年代末首次在小鼠中发现的，并且雌性小鼠对肝癌具有抵抗力。研究发现性激素会影响啮齿类动物的肝癌发病率。雌激素受体α（ERα）介导的雌激素信号传导或雄激素受体介导的雄激素信号传导分别预防或促进啮齿动物肝脏肿瘤的生长。叉头盒蛋白A（Foxa）因子，Foxa1和Foxa2，也被称为肝脏特化中的先驱转录因子，通过作为肝癌中性二型性的中心调节因子，对雌激素和雄激素信号传导都是必不可少的。本文就ERα与FOXA因子在肝癌中的相互作用进行综述，并对近年来在阐明肝癌性别二态性机制方面的突破性研究进行总结。
Liver cancer is the fifth most common cancer in human with male dominance. Sexual dimorphism of liver cancer is conserved from rodents to humans, which was firstly found in mice in late 1930s and female mice were resistant to liver cancer. Sex hormones were found to affect the incidence of liver cancer in rodents. Estrogen receptor alpha (ERα)-mediated estrogen signaling or androgen receptor-mediated androgen signaling prevents or promotes the growth of rodent liver tumors, respectively. Forkhead box protein A (Foxa) factors, Foxa1 and Foxa2, also known as pioneer transcription factors in liver specification, are essential for both estrogen and androgen signaling by acting as central regulators of sexual dimorphism in liver cancer. This review mainly focuses on the interplay between ERα and FOXA factors in liver cancer, and summarizes recent breakthrough studies in elucidating the mechanisms of sexual dimorphism in liver cancer.