Oxidative stress and schizophrenia: recent breakthroughs from an old story.
Oxidative stress and schizophrenia: recent breakthroughs from an old story.
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DOI：
10.1097/yco.0000000000000054
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发表时间：
2014-05
影响因子：
6.9
通讯作者：
Sawa A
中科院分区：
文献类型：
--
作者：
Emiliani FE;Sedlak TW;Sawa A
氧化应激已成为精神分裂症研究的一个令人兴奋的领域，并提供了充分的机会和希望，更好地了解其病理生理学，这可能会导致新的治疗策略。本文介绍了如何最近的方法学进展，使氧化应激的研究，以解决基本问题，并提供了一些概念上的突破，该领域。最近的人类研究支持这样一种观点，即对氧化应激的内在易感性可能是精神分裂症病理生理学的基础。不止一种可能与精神分裂症生物学研究相关的动物模型也显示出大脑中氧化应激的迹象。这些进展使这一主题对理解精神分裂症至关重要，并将在推进治疗方案方面发挥作用。这篇综述涵盖了从人类生物标本的经典生化研究到磁共振光谱学和新型小鼠模型的使用等主题，并重点突出了有前途的研究领域。
Oxidative stress has become an exciting area of schizophrenia research, and provides ample opportunities and hope for a better understanding of its pathophysiology, which may lead to novel treatment strategies. This review describes how recent methodological advances have allowed the study of oxidative stress to tackle fundamental questions and have provided several conceptual breakthroughs to the field. Recent human studies support the notion that intrinsic susceptibility to oxidative stress may underlie the pathophysiology of schizophrenia. More than one animal model that may be relevant to study biology of schizophrenia also shows sign of oxidative stress in the brain. These advances have made this topic of paramount importance to the understanding of schizophrenia, and will play a role in advancing treatment options. This review covers topics from classic biochemical studies of human biospecimens to the use of magnetic resonance spectroscopy and novel mouse models, and focuses on highlighting promising areas of research.