Multiplexed Bacterial Cell-Cell Communication via a Genetically Encoded CRISPRi-Based Multiplexer-Demultiplexer Circuit

Multiplexed Bacterial Cell-Cell Communication via a Genetically Encoded CRISPRi-Based Multiplexer-Demultiplexer Circuit
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通过基于 CRISPRi 的基因编码多路复用器-解复用器电路进行多路复用细菌细胞间通信

DOI:
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发表时间:
2016
期刊:
Annual International Conference on Nanoscale Computing and Communication
影响因子:
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通讯作者:
Jeffrey J. Tabor
Jeffrey J. Tabor
中科院分区:
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文献类型:
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作者:
John T. Sexton;Jeffrey J. Tabor

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活细胞可以通过遗传编码电路进行编程,以充当复杂的决策设备,细胞之间的通信可以促进日益复杂的群体级计算。在这项工作中,我们描述了一种新的表征平台,用于评估遗传编码电路的性能,我们展示了两个遗传编码的组合逻辑电路,一个多路复用器(MUX)和一个解复用器(DEMUX),它可以结合起来,以促进多个独立的信号之间的通信不同菌株的活细菌细胞。
Living cells can be programmed with genetically encoded circuits to function as sophisticated decision-making devices, and communication among cells can facilitate increasingly complex, population-level computations. In this work, we describe a novel characterization platform for assessing the performance of genetically encoded circuits, and we demonstrate two genetically encoded combinational logic circuits, a multiplexer (MUX) and a demultiplexer (DEMUX), which can be combined to facilitate the communication of multiple independent signals between different strains of living bacterial cells.
DOI: 10.1021/acssynbio.5b00284
发表时间: 2016-07-15
影响因子: 4.7
作者:
Castillo-Hair SM;Sexton JT;Landry BP;Olson EJ;Igoshin OA;Tabor JJ
通讯作者: Tabor JJ
DOI: 10.1021/acssynbio.5b00147
发表时间: 2016-01-15
影响因子: 4.7
作者:
Didovyk A;Borek B;Hasty J;Tsimring L
通讯作者: Tsimring L