Mitochondrial transcription factor A (TFAM): one actor for different roles
Mitochondrial transcription factor A (TFAM): one actor for different roles
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线粒体转录因子 A (TFAM):一位演员扮演不同的角色
DOI:
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发表时间:
2012
期刊:
影响因子:
--
通讯作者:
A. Lezza
中科院分区:
文献类型:
--
作者:
A. Lezza
Mitochondrial Transcription Factor A (TFAM) is a nuclear-encoded factor present in mitochondria from all kinds of animals, even with a homologous form in yeast, which has strongly and progressively gained an eminent relevance in the regulation of mitochondrial DNA (mtDNA) functions. This is due to the various functions performed by the protein, which cover a very wide scenario including: replication, transcription, maintenance and eventually repair of mtDNA molecules. In consideration of so many different roles it plays, it can be understood there is a deep interest in its regulation of expression and activity as well as its eventual involvement in pathologies related to a decreased functionality/presence of the mitochondrial genome and the consequences of TFAM induced overexpression.
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影响因子:
3.5
作者:
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通讯作者:
Suzuki, CK
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3.5
作者:
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DOI:
--
发表时间:
1993
期刊:
The Journal of biological chemistry
影响因子:
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DOI:
10.1016/s0021-9258(19)50739-6
发表时间:
1992-02
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
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通讯作者:
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