Mitochondrial transcription factor A (TFAM): one actor for different roles

Mitochondrial transcription factor A (TFAM): one actor for different roles
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线粒体转录因子 A (TFAM):一位演员扮演不同的角色

DOI:
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发表时间:
2012
期刊:
Frontiers in Biology
影响因子:
--
通讯作者:
A. Lezza
A. Lezza
中科院分区:
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文献类型:
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作者:
A. Lezza

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线粒体转录因子A(TFAM)是一种存在于各种动物线粒体中的核编码因子,在酵母中也有同源形式,在线粒体DNA(mtDNA)功能的调控中具有重要作用。这是由于蛋白质执行的各种功能,其涵盖非常广泛的场景,包括:mtDNA分子的复制,转录,维护和最终修复。考虑到它所起的如此多的不同作用,可以理解的是,人们对其表达和活性的调节以及其最终参与与线粒体基因组的功能性/存在降低相关的病理学和TFAM诱导的过表达的后果有着浓厚的兴趣。
Mitochondrial Transcription Factor A (TFAM) is a nuclear-encoded factor present in mitochondria from all kinds of animals, even with a homologous form in yeast, which has strongly and progressively gained an eminent relevance in the regulation of mitochondrial DNA (mtDNA) functions. This is due to the various functions performed by the protein, which cover a very wide scenario including: replication, transcription, maintenance and eventually repair of mtDNA molecules. In consideration of so many different roles it plays, it can be understood there is a deep interest in its regulation of expression and activity as well as its eventual involvement in pathologies related to a decreased functionality/presence of the mitochondrial genome and the consequences of TFAM induced overexpression.
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