Synthesis of alkyl α-aminomethyl-phenylphosphinates and N,N-bis(alkoxyphenylphosphinylmethyl)amines by the microwave-assisted Kabachnik-Fields reaction
Synthesis of alkyl α-aminomethyl-phenylphosphinates and N,N-bis(alkoxyphenylphosphinylmethyl)amines by the microwave-assisted Kabachnik-Fields reaction
复制标题
DOI：
10.1002/hc.21343
复制
发表时间：
2016-09-01
影响因子：
0.3
通讯作者：
Keglevich, Gyorgy
中科院分区：
文献类型：
--
作者：
Balint, Erika;Toth, Regina Eszter;Keglevich, Gyorgy
作为一种新的拓展，将Kabachnik-Fields反应应用于α-氨基甲基苯基次膦酸烷基酯的合成，并将双磷杂Mannich反应应用于双（烷氧基苯基膦基甲基）胺的合成。以烷基苯基次膦酸酯、多聚甲醛、伯胺或仲胺为原料，在微波辅助下无溶剂缩合，合成了27种新的氨基次膦酸酯衍生物。起始P物质也在微波条件下制备。还研究了N甲基化氨甲基-苯基次膦酸酯副产物的形成。
As a novel extension, the Kabachnik-Fields reaction was applied to the synthesis of alkyl a aminomethyl phenylphosphinates, and the double phospha Mannich reaction was utilized in the preparation of bis(alkoxyphenylphosphinylmethyl)amines. A total of 27 new aminophosphinate derivatives were synthesized by the microwave-assisted solvent free condensation of alkyl phenyl-H-phosphinates, paraformaldehyde, and primary or secondary amines. The starting P species were also prepared under microwave conditions. The formation of the N methylated aminomethyl-phenylphosphinate by products was also investigated.