Multiple-time replicability of near-infrared spectroscopy recording during prefrontal activation task in healthy men
Multiple-time replicability of near-infrared spectroscopy recording during prefrontal activation task in healthy men
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DOI：
10.1016/j.neures.2006.12.007
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发表时间：
2007-04-01
影响因子：
2.9
通讯作者：
Kato, Nobumasa
中科院分区：
文献类型：
--
作者：
Kono, Toshiaki;Matsuo, Koji;Kato, Nobumasa
近红外光谱（NIRS）具有潜在的临床应用在神经精神病学，因为它能够无创和方便的测量血流动力学反应的认知激活。在12名健康男性中，我们使用24通道近红外光谱，研究了在类别流畅性任务期间（每隔一周），前额叶皮层中氧合血红蛋白和脱氧血红蛋白浓度（[oxyHb]，[deoxyHb]）变化的可重复性。采用多种方法评价NIRS信号（[oxyHb]、[deoxyHb]）的幅度、位置和时间过程的可重复性。任务表现没有显着不同的会话，也没有显着相关的NIRS信号。重复测量方差分析和方差分量分析表明两个NIRS测量的量值具有较高的可重复性，而[oxyHb]会话间差异的效应大小不可忽略。显著激活通道的数量和空间位置对于这两种措施都是充分可复制的，除了显著激活通道的跨会话重叠在[deoxyHb]中很弱。激活的时间过程是可以接受的复制在两个措施。综上所述，这些发现表明，在男性认知激活过程中，多次测量前额叶血流动力学具有相当大的可复制性。有必要使用不同的条件进行进一步的研究，或评估干预后纵向变化的敏感性。(c)2006年Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
Near-infrared spectroscopy (NIRS) has the potential for clinical application in neuropsychiatry because it enables non-invasive and convenient measurement of hemodynamic response to cognitive activation. Using 24-channel NIRS in 12 healthy men, we examined the replicability of oxy-and deoxy-hemoglobin concentration ([oxyHb], [deoxyHb]) changes in the prefrontal cortex during the category fluency task over four repeated sessions (each I-week apart). Multiple methods were employed to evaluate the replicability of magnitude, location, and time course of the NIRS signals ([oxyHb], [deoxyHb]). Task performances did not differ significantly across sessions, nor were they significantly correlated with NIRS signals. Repeated measures ANOVA and variance component analysis indicated high replicability of magnitude for both NIRS measures, whereas the effect sizes of between-session differences in [oxyHb] were not negligible. The number and spatial location of significantly activated channels were sufficiently replicable for both measures, except that the across-session overlap of significantly activated channels was weak in [deoxyHb]. The time course of the activation was acceptably replicable in both measures. Taken together, these findings suggest there is considerable replicability of multiple-time measurements of prefrontal hemodynamics during cognitive activation in men. Further studies using different conditions or assessing sensitivity to longitudinal changes following interventions are necessary. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.