A quantitative theory of gamma synchronization in macaque V1.
A quantitative theory of gamma synchronization in macaque V1.
复制标题
猕猴V1中伽马同步的定量理论。
DOI：
10.7554/elife.26642
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发表时间：
2017-08-31
期刊：
影响因子：
7.7
通讯作者：
De Weerd P
中科院分区：
文献类型：
--
作者：
Lowet E;Roberts MJ;Peter A;Gips B;De Weerd P
伽马波段同步协调振荡神经元群体的短暂兴奋期，以优化感觉和认知过程中的信息传输。通常，随着时间的推移，稳定的共享频率被认为是功能性神经同步的条件。在这里，我们证明了相反的：瞬时频率调制是至关重要的，以调节相位关系和同步。在猴视觉V1区，不同视觉刺激驱动的附近局部种群表现出不同的γ频率。当足够相似时，这些频率不断地相互吸引和排斥，这使得优选的相位关系能够在最小化频率差的周期内保持。至关重要的是，频率和相位在各种刺激条件下的精确动态是从描述弱耦合振荡器如何影响彼此相位关系的物理理论中预测的。因此，通过瞬时频率调制实现同步的基本数学原理适用于V1中的伽马，并且可能可推广到其他大脑区域和节律。
Gamma-band synchronization coordinates brief periods of excitability in oscillating neuronal populations to optimize information transmission during sensation and cognition. Commonly, a stable, shared frequency over time is considered a condition for functional neural synchronization. Here, we demonstrate the opposite: instantaneous frequency modulations are critical to regulate phase relations and synchronization. In monkey visual area V1, nearby local populations driven by different visual stimulation showed different gamma frequencies. When similar enough, these frequencies continually attracted and repulsed each other, which enabled preferred phase relations to be maintained in periods of minimized frequency difference. Crucially, the precise dynamics of frequencies and phases across a wide range of stimulus conditions was predicted from a physics theory that describes how weakly coupled oscillators influence each other’s phase relations. Hence, the fundamental mathematical principle of synchronization through instantaneous frequency modulations applies to gamma in V1 and is likely generalizable to other brain regions and rhythms.