SMP domain proteins in membrane lipid dynamics
SMP domain proteins in membrane lipid dynamics
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DOI：
10.1016/j.bbalip.2019.04.007
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发表时间：
2020-01-01
影响因子：
4.8
通讯作者：
Saheki, Yasunori
中科院分区：
文献类型：
--
作者：
Jeyasimman, Darshini;Saheki, Yasunori
突触素样脂结合(SMP)结构域蛋白是真核生物中进化保守的蛋白质家族，定位于内质网(ER)和质膜(PM)或其他细胞器之间。它们通过与其他蛋白质和膜脂的相互作用参与这些膜接触部位的连接。最近的结构和生化研究表明，SMP结构域蛋白通过其独特的疏水空腔携带脂类的能力运输多种脂质物种。越来越多的证据表明，SMP结构域蛋白通过作用于膜接触部位而在细胞生理学中发挥重要作用。本文综述了SMP结构域蛋白的功能及其在脂类跨膜转运中的直接作用。我们还讨论了它们在生物体中的生理功能，以及在膜接触部位与SMP结构域蛋白平行作用的“旁路”途径。
Synaptotagmin-like mitochondrial-lipid-binding (SMP) domain proteins are evolutionarily conserved family of proteins in eukaryotes that localize between the endoplasmic reticulum (ER) and either the plasma membrane (PM) or other organelles. They are involved in tethering of these membrane contact sites through interaction with other proteins and membrane lipids. Recent structural and biochemical studies have demonstrated that SMP domain proteins transport a wide variety of lipid species by the ability of the SMP domain to harbor lipids through its unique hydrophobic cavity. Growing evidence suggests that SMP domain proteins play critical roles in cell physiology by their actions at membrane contact sites. In this review, we summarize the functions of SMP domain proteins and their direct roles in lipid transport across different membrane compartments. We also discuss their physiological functions in organisms as well as "bypass" pathways that act in parallel with SMP domain proteins at membrane contact sites.