Digital stereo image analyzer for generating automated 3-D measures of optic disc deformation in glaucoma.
Digital stereo image analyzer for generating automated 3-D measures of optic disc deformation in glaucoma.
复制标题
数字立体图像分析仪，用于生成青光眼视盘变形的自动 3D 测量结果。
DOI：
10.1109/tmi.2002.806293
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Soliz,Peter
中科院分区：
文献类型：
--
作者：
Corona,Enrique;Mitra,Sunanda;Wilson,Mark;Krile,Thomas;Kwon,YoungH;Soliz,Peter
在目前的临床情况下，视网膜结构的精确评估的主要限制是缺乏标准化，在视网膜图像的解释中所涉及的固有的主观性，以及观察者内和观察者间的差异。在评价青光眼的视盘变形时，可以通过使用先进的数字图像分析技术从立体视盘图像对中生成精确的指标来克服这些局限性。提出了一种数字立体视觉系统，用于从立体视盘图像中可视化视神经乳头的地形图。我们已经开发了一种算法，结合功率倒谱和零均值归一化互相关技术，提取深度信息，使用粗到细的立体声对中相应的窗口之间的视差。灰度级编码的稀疏视差矩阵进行三次B样条操作，以生成平滑表示的视杯/盘表面和新的三维（3-D）度量从isodispity轮廓。尽管在3-D表面恢复所涉及的挑战，我们的算法在使用的约束范围内找到差异的鲁棒性已被验证使用立体对与已知的差异。在青光眼患者的初步纵向研究中，发现计算机生成的定量杯/盘体积指标与临床常用的手动指标之间存在很强的相关性。然而，计算机生成的新指标消除了主观可变性，并大大减少了青光眼随访研究中手动生成指标所涉及的时间和成本。
The major limitations of precise evaluation of retinal structures in present clinical situations are the lack of standardization, the inherent subjectivity involved in the interpretation of retinal images, and intra- as well as interobserver variability. While evaluating optic disc deformation in glaucoma, these limitations could be overcome by using advanced digital image analysis techniques to generate precise metrics; from stereo optic disc image pairs. A digital stereovision system for visualizing the topography of the optic nerve head from stereo optic disc images is presented. We have developed an algorithm, combining power cepstrum and zero-mean-normalized cross correlation techniques, which extracts depth information using coarse-to-fine disparity between corresponding windows in a stereo pair. The gray level encoded sparse disparity matrix is subjected to a cubic B-spline operation to generate smooth representations of the optic cup/disc surfaces and new three-dimensional (3-D) metrics from isodisparity contours. Despite the challenges involved in 3-D surface recovery, the robustness of our algorithm in finding disparities within the constraints used has been validated using stereo pairs with known disparities. In a preliminary longitudinal study of glaucoma patients, a strong correlation is found between the computer-generated quantitative cup/disc volume metrics and manual metrics commonly used in a clinic. The computer generated new metrics, however, eliminate the subjective variability and greatly reduce the time and cost involved in manual metric generation in follow-up studies of glaucoma.