Dysregulation of long non-coding RNA profile in peripheral blood of multiple sclerosis patients
Dysregulation of long non-coding RNA profile in peripheral blood of multiple sclerosis patients
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DOI：
10.1016/j.msard.2018.07.044
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发表时间：
2018-10-01
影响因子：
4
通讯作者：
Taheri, Mohammad
中科院分区：
文献类型：
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作者：
Dastmalchi, Romina;Ghafouri-Fard, Soudeh;Taheri, Mohammad
多发性硬化症（MS）是一种慢性自身免疫性疾病，其中几种免疫相关基因的失调或异常表达已被注意到。最近，长链非编码RNA（lncRNA）在免疫应答调节中的参与已被强调。本研究检测了50例复发缓解型MS患者和50例健康对照者外周血中3种lncRNA的表达水平，分别为NEAT 1、PANDA和TUG1。与健康受试者相比，所有三种lncRNA在MS患者中均显著过表达。此外，在患者组中，这三种lncRNA的表达水平之间存在显著相关性。女性患者NEAT 1表达与发病年龄和病程呈负相关。此外，TUG1表达与女性患者的疾病持续时间呈负相关。本研究为lncRNA在MS发病机制中的作用提供了进一步的证据。
Multiple sclerosis (MS) is a chronic autoimmune disorder in which dysregulation or aberrant expressions of several immune-related genes have been noted. More recently, the participation of long non-coding RNAs (lncRNAs) in regulation of immune responses has been highlighted. In the present study, we evaluated expression levels of three lncRNAs named Nuclear Paraspeckle Assembly Transcript 1 (NEAT1), P21 associated ncRNA DNA damage activated (PANDA) and Taurine-up-regulated gene 1 (TUG1) in peripheral blood of 50 relapsing-remitting MS patients and 50 matched healthy subjects. All three lncRNAs have been significantly over-expressed in MS patients compared with healthy subjects. In addition, significant correlations were found between expression levels of these three lncRNAs in the patients group. NEAT1 expression was inversely correlated with age at onset and disease duration in female patients. Moreover, TUG1 expression was inversely correlated with disease duration in female patients. The present study provides further evidences for the role of lncRNAs in pathogenesis of MS.