Bilateral Cancer of the Breast
Bilateral Cancer of the Breast
复制标题
双侧乳腺癌
作者：
M. R. del Turco;S. Ciatto;G. Perigli;D. Borrelli;M. Carcangiu;M. Santucci
作者回顾了2311例原发性乳腺癌根治术后随访1 ~ 11年的病例。在研究期间观察到28例同时发生和40例异时发生的对侧乳腺癌，平均年发病率为4.5%。首次癌症诊断时年龄较小和小叶癌的组织学证据与对侧癌症显着相关，而第一个癌症分期似乎不是一个风险因素。同侧异时性癌显著恶化了预期的预后，而同时发生的双侧癌则不然。这种负面的预后影响的第二个乳腺癌和预防措施，如对侧乳房切除术的作用的可能原因进行了讨论。目前，每年进行一次准确的临床乳房X线随访似乎是最可取的做法。
The authors reviewed a series of 2311 primary breast cancers followed-up from 1 to 11 years after radical mastectomy. Twenty-eight simultaneous and 40 metachronous contralateral breast cancers were observed in the study period with an average annual incidence rate of 4.5%. Younger age and histologic evidence of lobular carcinoma at first cancer diagnosis was significantly associated with contralateral cancer, whereas first cancer stage did not seem to be a risk factor. Contralateral metachronous cancer significantly worsened the expected prognosis, which was not true for simultaneous bilateral cancers. The possible reasons for this negative prognostic influence of a second breast cancer and the role of preventive measures such as contralateral mastectomy are discussed. At the present time, an accurate annual clinicomammographic follow-up seems to be the most advisable course of action.