DETECTION OF NONEXUDATIVE CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
DETECTION OF NONEXUDATIVE CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
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DOI：
10.1097/iae.0000000000000867
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发表时间：
2015-11
期刊：
影响因子：
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通讯作者：
Bailey ST
中科院分区：
文献类型：
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作者：
Palejwala NV;Jia Y;Gao SS;Liu L;Flaxel CJ;Hwang TS;Lauer AK;Wilson DJ;Huang D;Bailey ST
目的：评估眼睛与年龄相关性黄斑变性和高风险的特征，脉络膜新生血管（CNV）与光学相干断层扫描（OCT）血管造影，以确定是否早期检测CNVispossible.Methods：眼睛玻璃疣，色素变化，并与CNV在对侧眼进行了扫描与70 kHz的光谱域OCT系统（Optovue RTVue-XR Avanti）。使用分裂谱振幅去相关血管造影（SSADA）算法区分血流和静态组织。两名蒙面分级员审查了CNV的扫描，CNV定义为外部视网膜/RPE下板中的血流。结果：32只眼中，OCT血管造影发现2只眼（6%）为1型CNV。病变与荧光素血管造影或OCT上的液体渗漏无关。1例随访8个月未治疗，OCT上CNV流动面积略有扩大，无液体积聚或视力丧失。结论：光学相干断层血管造影可检出非渗出性CNV，而荧光素血管造影和OCT难以鉴别的病变，其临床意义和自然病程尚需进一步研究。
Purpose:To evaluate eyes with age-related macular degeneration and high-risk characteristics for choroidal neovascularization (CNV) with optical coherence tomographic (OCT) angiography to determine whether earlier detection of CNV is possible.Methods:Eyes with drusen, pigmentary changes, and with CNV in the fellow eye were scanned with a 70-kHz spectral domain OCT system (Optovue RTVue-XR Avanti). The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was used to distinguish blood flow from static tissue. Two masked graders reviewed scans for CNV, defined as flow in the outer retinal/sub-RPE slab. Choroidal neovascularization flow area repeatability and between-grader reproducibility were calculated.Results:Of 32 eyes, 2 (6%) were found to have Type 1 CNV with OCT angiography. The lesions were not associated with leakage on fluorescein angiography or fluid on OCT. One case was followed for 8 months without treatment, and the CNV flow area enlarged slightly without fluid buildup on OCT or vision loss. Between-grader reproducibility of the CNV flow area was 9.4%(coefficient of variation) and within-visit repeatability was 5.2%(pooled coefficient of variation).Conclusion:Optical coherence tomographic angiography can detect the presence of nonexudative CNV, lesions difficult to identify with fluorescein angiography and OCT. Further study is needed to understand the significance and natural history of these lesions.