Higher incidence of depression preceding the onset of Parkinson's disease: A register study
Higher incidence of depression preceding the onset of Parkinson's disease: A register study
复制标题
DOI：
10.1002/mds.10387
复制
发表时间：
2003-04-01
影响因子：
8.6
通讯作者：
Verhey, FRJ
中科院分区：
文献类型：
--
作者：
Leentjens, AFG;Van den Akker, M;Verhey, FRJ
尽管帕金森氏病(PD)前抑郁症的病史表明这两种疾病之间可能存在病理生理关系，但目前还没有流行病学证据支持这一观点。我们比较了后来诊断为帕金森病的患者与匹配的对照组人群中抑郁的发生率。使用正在进行的基于全科实践的登记研究的数据，计算患者在被诊断为帕金森病之前的终生抑郁障碍发生率，并与同一登记中匹配的对照人群进行比较。在分析时，登记册保存了105,416人的信息。在他们被诊断为帕金森病时，9.2%的患者有抑郁史，而对照组为4.0%(X(2)=22.388，df=1，P<；0.001)。这些患者有抑郁史的优势比为2.4(95%可信区间：2.1-2.7)。我们的结论是，后来被诊断为帕金森病的患者抑郁的发生率更高，这支持了这些患者存在抑郁的生物危险因素的假说。(C)2003年行动障碍会。
Although case histories of depression preceding Parkinson's disease (PD) point to a possible pathophysiological relationship between these two disorders, there is as yet no epidemiological evidence to support this view. We compared the incidence of depression in patients later diagnosed with PD, with that of a matched control population. Using data from an ongoing general practice-based register study, the lifetime incidence of depressive disorder was calculated for patients until their diagnosis of PD and compared with that of a matched control population from the same register. At the time of analysis, the register held information on 105,416 people. At the time of their diagnosis of PD, 9.2% of the patients had a history of depression, compared with 4.0% of the control population (chi(2) = 22.388, df = 1, P < 0.001). The odds ratio for a history of depression for these patients was 2.4 (95 % CI: 2.1-2.7). We concluded that the higher incidence of depression in patients who were later diagnosed with PD supports the hypothesis of there being a biological risk factor for depression in these patients. (C) 2003 Movement Disorder Society.