Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought
Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought
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DOI：
10.1179/174313209x393564
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发表时间：
2009-03-01
影响因子：
1.9
通讯作者：
Zhang, John H.
中科院分区：
文献类型：
--
作者：
Pluta, Ryszard M.;Hansen-Schwartz, Jacob;Zhang, John H.
目的：迟发性脑血管痉挛长期以来被认为是颅内动脉瘤破裂成功治疗后预后不良的重要原因，但尽管半个多世纪以来的深入研究，它仍然是一个病理生理之谜。方法：本文综述了来自北美、欧洲和亚洲的研究亮点，反映了对延迟性缺血缺陷的认识的最新进展。结果：本文将重点介绍目前公认的血管痉挛机制和血管痉挛研究的新领域。结论：关键问题是识别动脉狭窄以外的事件，如早期脑损伤和皮质扩张性抑制，以及它们对总体死亡率和发病率的贡献。[神经科学进展，2009；31日:151 - 158)
Objective: Delayed cerebral vasospasm has long been recognized as an important cause of poor outcome after an otherwise successful treatment of a ruptured intracranial aneurysm, but it remains a pathophysiological enigma despite intensive research for more than half a century.Method: Summarized in this review are highlights of research from North America, Europe and Asia reflecting recent advances in the understanding of delayed ischemic deficit.Result: It will focus on current accepted mechanisms and on new frontiers in vasospasm research.Conclusion: A key issue is the recognition of events other than arterial narrowing such as early brain injury and cortical spreading depression and of their contribution to overall mortality and morbidity. [Neurol Res 2009; 31: 151-158]