Language processing is strongly left lateralized in both sexes - Evidence from functional MRI
Language processing is strongly left lateralized in both sexes - Evidence from functional MRI
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DOI：
10.1093/brain/122.2.199
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发表时间：
1999-02-01
期刊：
影响因子：
14.5
通讯作者：
Cox, RW
中科院分区：
文献类型：
--
作者：
Frost, JA;Binder, JR;Cox, RW
功能性磁共振成像（fMRI）被用来研究性别对语言理解任务中大脑激活的影响。研究了大量的受试者（50名女性和50名男性），以最大限度地提高统计功效，发现两性之间的细微差异。为了估计与性别差异相关的结果的特异性，对两组随机分配的受试者进行了平行分析。男性和女性表现出非常相似的，强烈的左侧激活模式。整体激活模式的组间差异的体素测试表明，女性和男性之间没有显着差异。在进一步的分析中，通过感兴趣的区域和半球检查组差异。在任何感兴趣的区域或半球内皮层激活模式的活动偏侧化方面，性别之间没有差异。这些数据反对男性和女性在语言过程的大规模神经组织中存在实质性差异。
Functional MRI (fMRI) was used to examine gender effects on brain activation during a language comprehension task. A large number of subjects (50 women and 50 men) was studied to maximize the statistical power to detect subtle differences between the sexes. To estimate the specificity of findings related to sex differences, parallel analyses were performed on two groups of randomly assigned subjects. Men and women showed very similar, strongly left lateralized activation patterns. Voxel-wise tests for group differences in overall activation patterns demonstrated no significant differences between women and men. In further analyses, group differences were examined by region of interest and by hemisphere. No differences were found between the sexes in lateralization of activity in any region of interest or in intrahemispheric cortical activation patterns, These data argue against substantive differences between men and women in the large-scale neural organization of language processes.