Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
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DOI：
10.1126/science.abj8222
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发表时间：
2022-01-21
期刊：
影响因子：
56.9
通讯作者：
Ascherio, Alberto
中科院分区：
文献类型：
--
作者：
Bjornevik, Kjetil;Cortese, Marianna;Ascherio, Alberto
多发性硬化（MS）是一种病因不明的中枢神经系统慢性炎性脱髓鞘疾病。我们测试了MS是由EB病毒（EBV）引起的这一假设，该假设在一个由1000多万美国军队现役年轻人组成的队列中进行，其中955人在服役期间被诊断患有MS。感染EBV后MS的风险增加32倍，但感染其他病毒（包括类似传播的巨细胞病毒）后没有增加。血清神经丝轻链水平，神经轴突变性的生物标志物，仅在EBV血清转换后增加。这些发现不能用任何已知的MS风险因素来解释，并表明EBV是MS的主要原因。
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom were diagnosed with MS during their period of service. Risk of MS increased 32-fold after infection with EBV but was not increased after infection with other viruses, including the similarly transmitted cytomegalovirus. Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.