Association of Coronary Heart Disease incidence with carotid arterial wall thickness and major risk factors: The Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993
Association of Coronary Heart Disease incidence with carotid arterial wall thickness and major risk factors: The Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993
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DOI：
10.1093/oxfordjournals.aje.a009302
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发表时间：
1997-09-15
影响因子：
5
通讯作者：
Clegg, LX
中科院分区：
文献类型：
--
作者：
Chambless, LE;Heiss, G;Clegg, LX
很少有研究确定无症状个体中颈动脉内膜 - 中层厚度（IMT）增加是否前瞻性地与冠心病（CHD）风险增加相关。在社区动脉粥样硬化风险研究中，颈动脉IMT作为全身性动脉粥样硬化的一个指标，被定义为使用B型超声在颈动脉六个部位测量的IMT平均值。作者评估了它与美国四个社区（北卡罗来纳州福赛斯县、密西西比州杰克逊市、明尼苏达州明尼阿波利斯市和马里兰州华盛顿县）年龄在45 - 64岁的7289名女性和5552名男性样本在4 - 7年随访期（1987 - 1993年）内冠心病发病率的关系，这些人在基线时无临床冠心病。女性有96例发病事件，男性有194例。在仅根据年龄、种族和研究中心调整的性别特异性Cox比例风险模型中，比较极端平均IMT（大于或等于1mm）与非极端（此处未完整，请检查原文）的风险比。
Few studies have determined whether greater carotid artery intima-media thickness (IMT) in asymptomatic individuals is associated prospectively with increased risk of coronary heart disease (CHD). In the Atherosclerosis Risk in Communities Study, carotid IMT, an index of generalized atherosclerosis, was defined as the mean of IMT measurements at six sites of the carotid arteries using B-mode ultrasound. The authors assessed its relation to CHD incidence over 4-7 years of follow-up (1987-1993) in four US communities (Forsyth County, North Carolina; Jackson, Mississippi; Minneapolis, Minnesota; and Washington County, Maryland) from samples of 7,289 women and 5,552 men aged 45-64 years who were free of clinical CHD at baseline. There were 96 incident events for women and 194 for men. In sex-specific Cox proportional hazards models adjusted only for age, race, and center, the hazard rate ratio comparing extreme mean IMT(greater than or equal to 1 mm) to not extreme (