The Posterior Parietal Cortex (PPC) Mediates Anticipatory Motor Control
The Posterior Parietal Cortex (PPC) Mediates Anticipatory Motor Control
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DOI：
10.1016/j.brs.2014.08.003
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发表时间：
2014-11-01
影响因子：
7.7
通讯作者：
Pollok, Bettina
中科院分区：
文献类型：
--
作者：
Krause, Vanessa;Weber, Juliane;Pollok, Bettina
背景：灵活和精确定时的运动控制是基于皮质-皮质下网络内的功能相互作用。左后顶叶皮层（PPC）被认为是通过感觉运动反馈匹配进行预期运动控制的关键。目的：本研究的目的是解开左PPC与使用经颅直流电刺激（tDCS）进行预期运动控制的特定相关性，因为因果关系尚待建立。方法：在16名右利手受试者的左侧PPC上，在单独的会话中应用阳极与阴极tDCS 10分钟。左侧初级运动皮层（M1）tDCS作为对照条件，并应用于另外15名受试者。之前和之后立即tDCS，受试者进行三项任务，要求时间运动精度相对于。听觉刺激：结果：左侧PPC tDCS影响右手同步，但不影响简单反应时。运动预测恶化阳极tDCS，而阴极tDCS产生相反的效果。间隔繁殖的变异性增加阳极左M1 tDCS，而阴极tDCS减少。简单的反应时间没有显着的影响被发现。结论：目前的数据支持的假设，左PPC是因果关系参与右手预期电机控制超过纯电机的实现M1处理，并可能表明主观的时间。由于M1 tDCS特别影响运动执行，所观察到的PPC效应不太可能通过运动皮层兴奋性的改变来解释。(C)2014爱思唯尔公司All rights reserved.
Background: Flexible and precisely timed motor control is based on functional interaction within a cortico-subcortical network. The left posterior parietal cortex (PPC) is supposed to be crucial for anticipatory motor control by sensorimotor feedback matching.Objective: Intention of the present study was to disentangle the specific relevance of the left PPC for anticipatory motor control using transcranial direct current stimulation (tDCS) since a causal link remains to be established.Methods: Anodal vs. cathodal tDCS was applied for 10 min over the left PPC in 16 right-handed subjects in separate sessions. Left primary motor cortex (M1) tDCS served as control condition and was applied in additional 15 subjects. Prior to and Immediately after tDCS, subjects performed three tasks demanding temporal motor precision with respect to an. auditory stimulus: sensorimotor synchronization as measure of anticipatory motor control, interval reproduction and simple reaction.Results: Left PPC tDCS affected right hand synchronization but not simple reaction times. Motor anticipation was deteriorated by anodal tDCS, while cathodal tDCS yielded the reverse effect. The variability of interval reproduction was increased by anodal left M1 tDCS, whereas it was reduced by cathodal tDCS. No significant effects on simple reaction times were found.Conclusion: The present data support the hypothesis that left PPC is causally involved in right hand anticipatory motor control exceeding pure motor implementation as processed by M1 and possibly indicating subjective timing. Since M1 tDCS particularly affects motor implementation, the observed PPC effects are not likely to be explained by alterations of motor-cortical excitability. (C) 2014 Elsevier Inc. All rights reserved.