Chronic mood disorders in depressed outpatient--diagnosis and response to pharmacotherapy.
Chronic mood disorders in depressed outpatient--diagnosis and response to pharmacotherapy.
复制标题
抑郁症门诊患者的慢性情绪障碍——诊断和对药物治疗的反应。
DOI：
10.1016/0165-0327(80)90007-5
复制
发表时间：
1980
影响因子：
6.6
通讯作者：
Prusoff,BA
中科院分区：
文献类型：
--
作者：
Rounsaville,BJ;Sholomskas,D;Prusoff,BA
目前的研究旨在评估用于对轻微情绪障碍进行分类的研究诊断标准(RDC)类别的实用性。类似的分类将用于APA的诊断和统计手册，第3版。患者样本包括连续接受阿米替林、奋乃静及其联合治疗抑郁症的双盲试验的。目前患有严重抑郁障碍的患者接受为期4周的药物治疗。慢性情绪障碍也使用RDC标准进行评估。这项评估显示，只有34%的人符合严重抑郁障碍发作的标准，而36%的人符合间歇性抑郁障碍的标准，14%的人符合环胸型人格的标准，16%的人除了目前的严重抑郁发作外，还符合性格不稳定的标准。这4个诊断亚组在人口学特征、儿童史、精神病史、症状和社会功能的表现模式以及对治疗的反应方面进行了比较。在呈现症状水平和残留损害方面，各亚组之间存在差异。然而，在有和没有慢性轻微情绪障碍的患者中，对简短的抗抑郁药物治疗没有不同的反应。大多数患者在短暂的疗程中都有改善。因此，慢性轻微情绪障碍的存在似乎并不是目前正在经历严重抑郁发作的患者使用药物的禁忌症。
The current study was devised to assess the utility of Research Diagnostic Criteria (RDC) categories used to classify minor mood disorders. Similar categories are to be used in the APA'sDiagnostic and Statistical Manual, 3rd edition. The patient sample consisted of 64 consecutive admissions to a double-blind trial of amitriptyline, perphenazine and the combination as treatment for depression. Patients who met RDC for a current episode of major depressive disorder were given 4 weeks of pharmacotherapy as treatment.Chronic mood disorders were also assessed using RDC criteria. This evaluation revealed that only 34% met criteria for an episode of major depressive disorder alone, while 36% met criteria for intermittent depressive disorder, 14% for cyclothymic personality and 16% for labile personality in addition to being in a current major depressive episode. These 4 diagnostic subgroups were compared on demographic characteristics, childhood history, psychiatric history, presenting patterns of symptoms and social functioning, and response to treatment. Differences were noted in the subgroups in presenting symptom levels and residual impairment. However, there wasno differential response to a brief course of antidepressant pharmacotherapy in patients with and without chronic minor mood disorders. Most patients showed an improvement during the brief course of treatment. Thus, the presence of a chronic minor mood disorder does not appear to be a contraindication for use of medication in patients who also are currently experiencing a major depressive episode.