Autophagy following heat stress: the role of aging and protein nitration.
Autophagy following heat stress: the role of aging and protein nitration.
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DOI：
10.4161/auto.6768
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发表时间：
2008-10
期刊：
影响因子：
13.3
通讯作者：
Oberley TD
中科院分区：
文献类型：
--
作者：
Swanlund JM;Kregel KC;Oberley TD
压力可以有多种来源（如物理、化学等），并导致蛋白质变性、DNA损伤，甚至可能导致死亡。为了防止这种有害的后果，大多数生物体都有一种或多种方法来抵消甚至阻止来自给定压力源的有害影响。生物体的这种补偿被称为应激反应；这包括抑制管家基因和随后与应激反应相关的基因的激活。被广泛研究的应激反应基因之一是被称为热休克蛋白（HSPs）的分子伴侣蛋白家族。我们实验室的工作与许多其他研究一致，表明应激诱导的热休克蛋白合成与年龄有关。热休克蛋白的可用性和/或功能随着年龄的增长而下降，可导致受损蛋白的积累，进而损害细胞。最近，我们的实验室发现热应激后大鼠肝细胞线粒体损伤显著增加，自噬增加。这些结果，以及随着年龄增长而增加的蛋白质硝化的发现，表明活性氮物种（RNS）在热应激后老龄大鼠热休克诱导能力下降和肝细胞病理增加中发挥了主要作用。
Stress can originate from a variety of sources (e.g. physical, chemical, etc.) and cause protein denaturation, DNA damage, and possibly death. In an effort to prevent such deleterious consequences, most organisms possess one or more ways to counteract or even prevent the harmful effect(s) from a given stressor. Such compensation by an organism is known as a stress response; this involves inhibition of housekeeping genes and subsequent activation of genes associated with the stress response. One of the most widely studied groups of stress response genes is a family of molecular chaperones known as heat shock proteins (HSPs). Work from our laboratory agrees with many other studies showing an age-related decline in stress-induced synthesis of HSPs. A decline in the availability and/or function of HSPs with age can lead to accumulation of damaged proteins, which in turn damages cells. Recently, our laboratory found a significant increase in mitochondrial damage as well as evidence of increased autophagy in rat hepatocytes following heat stress. These results, along with findings of increased protein nitration with age, suggest a major role for reactive nitrogen species (RNS) in both the decline in HSP induction and increased hepatocyte pathology observed in old rats following heat stress.
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影响因子：
2.3
作者：
Mayhew, TM;Griffiths, G;Lucocq, JM
通讯作者：
Lucocq, JM
影响因子：
13.3
作者：
Moore, Michael N.
通讯作者：
Moore, Michael N.
影响因子：
3.2
作者：
Nithipongvanitch, Rarnaneeya;Ittarat, Wanida;Oberley, Terry D.
通讯作者：
Oberley, Terry D.
影响因子：
4.8
作者：
Cuervo, AM;Dice, JF
通讯作者：
Dice, JF
大鼠肝细胞中蛋白质降解、自噬封存和线粒体糖摄取的温度依赖性
DOI：
10.1016/0167-4889(87)90167-4
发表时间：
1987-07-06
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
--
作者：
GORDON, PB;KOVACS, AL;SEGLEN, PO
通讯作者：
SEGLEN, PO