Hybrid PET/MR Imaging and Brain Connectivity.
Hybrid PET/MR Imaging and Brain Connectivity.
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DOI：
10.3389/fnins.2016.00064
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发表时间：
2016
影响因子：
4.3
通讯作者：
Salvatore M
中科院分区：
文献类型：
--
作者：
Aiello M;Cavaliere C;Salvatore M
近年来，脑连通性越来越受到跨学科研究界的关注。脑连通性研究的特点是多方面的方法，在不同的尺度上提供大脑区域之间关系的结构和功能证据。虽然磁共振（MR）是研究体内连通性的最成熟的成像方式，但最近出现的混合正电子发射断层扫描(PET)/MR扫描仪为更全面地研究大脑组织和生理铺平了道路。由于放射性示踪剂的高灵敏度和生化特异性，将MR与PET成像结合可以通过引入代谢连通性和cometomics的概念来丰富我们研究连通性的能力，并促进对高级神经组织背后的生理和分子基础的新见解。本文综述了磁共振成像和核医学中脑连通性分析的主要方法。此外，它将讨论利用混合PET/MR成像来研究生理过程和大脑连接的关系的实际方面和最先进的技术。
In recent years, brain connectivity is gaining ever-increasing interest from the interdisciplinary research community. The study of brain connectivity is characterized by a multifaceted approach providing both structural and functional evidence of the relationship between cerebral regions at different scales. Although magnetic resonance (MR) is the most established imaging modality for investigating connectivity in vivo, the recent advent of hybrid positron emission tomography (PET)/MR scanners paved the way for more comprehensive investigation of brain organization and physiology. Due to the high sensitivity and biochemical specificity of radiotracers, combining MR with PET imaging may enrich our ability to investigate connectivity by introducing the concept of metabolic connectivity and cometomics and promoting new insights on the physiological and molecular bases underlying high-level neural organization. This review aims to describe and summarize the main methods of analysis of brain connectivity employed in MR imaging and nuclear medicine. Moreover, it will discuss practical aspects and state-of-the-art techniques for exploiting hybrid PET/MR imaging to investigate the relationship of physiological processes and brain connectivity.