Diet and C-reactive protein.
Diet and C-reactive protein.
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DOI：
10.1007/s11883-003-0032-z
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发表时间：
2003-11-01
影响因子：
5.8
通讯作者：
Clifton, Peter M
中科院分区：
文献类型：
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作者：
Clifton, Peter M
c -反应蛋白（CRP）是健康个体和已有疾病患者心血管事件的独立预测因子。它也可能有助于疾病的发展。肥胖人群的CRP水平更高，这几乎可以肯定是因为胰岛素抵抗的增加。改变胰岛素抵抗的干预措施，如减肥、运动和共轭亚油酸，也会改变CRP。血糖负荷与CRP有关，但没有干预改变宏量营养素组成。在减肥的背景下，常量营养素的组成可能并不重要。酒精会降低CRP，但其机制尚不清楚。性别和肥胖之间的相互作用需要进一步的研究，但肥胖似乎对女性的CRP水平有更大的影响。
C-reactive protein (CRP) is an independent predictor of cardiovascular events in healthy individuals and those with pre-existing disease. It also probably contributes to the disease process. CRP levels are higher in obese subjects and this link is almost certainly because of increased insulin resistance. Interventions that alter insulin resistance, such as weight loss, exercise, and conjugated linoleic acid, also alter CRP. Glycemic load is associated with CRP, but there have been no interventions with altered macronutrient composition. In the context of weight loss, macronutrient composition is probably not important. Alcohol lowers CRP, but the mechanism is unknown. The interaction between gender and obesity needs further work, but it appears that obesity has a greater effect on CRP levels in women.