Hematological and biochemical parameters for Chinese rhesus macaque
Hematological and biochemical parameters for Chinese rhesus macaque
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DOI：
10.1371/journal.pone.0222338
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发表时间：
2019-09-17
期刊：
影响因子：
3.7
通讯作者：
He, Zhanlong
中科院分区：
文献类型：
--
作者：
Yu, Wenhai;Hao, Xianhui;He, Zhanlong
恒河猴是生物医学研究，特别是人类疾病、发育、转化和临床前研究的重要动物模型。血液生理生化指标是生理、病理、毒理研究的重要指标。然而，这些参数还没有系统的报告，为中国恒河猴。为了表征这些参数的参考，本研究收集了1805只生活在中国西南部的中国恒河猴。测定了24项血液生理指标和27项生化指标。发现性别和年龄影响这些参数。总之，本研究建立了一个比较全面、系统的中国猕猴血液学和生化指标参考值。这些参考将有益于以恒河猴为动物模型的生物医学研究。
Rhesus macaque is an important animal model in biomedical research, especially human disease, developmental, translational, and pre-clinical research. Blood physiological and biochemical parameters are important markers for physiology, pathology, and toxicology research. However, these parameters have not been systematically reported for Chinese rhesus macaques. To characterize the reference for these parameters, this study collected 1805 Chinese rhesus macaques living in Southwestern China. A total of 24 blood physiological indexes and 27 biochemical parameters were determined. Sex and age were found to affect these parameters. In conclusion, a comprehensive and systematic reference of hematological and biochemical parameters for Chinese rhesus macaque was established in this work on the basis of a large cohort. Such reference will benefit biomedical research employing rhesus macaques as animal models.