Movies of Molecular Motions and Reactions: The Single-Molecule, Real-Time Transmission Electron Microscope Imaging Technique
Movies of Molecular Motions and Reactions: The Single-Molecule, Real-Time Transmission Electron Microscope Imaging Technique
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DOI：
10.1002/anie.201205693
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发表时间：
2013-01-01
影响因子：
16.6
通讯作者：
Nakamura, Eiichi
中科院分区：
文献类型：
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作者：
Nakamura, Eiichi
1665 年，罗伯特·胡克 (Robert Hooke) 在其非常成功的显微和望远镜图像图画书《显微图画》 (Micrographia) 中自豪地宣称：“事实是，长期以来，自然科学一直只是大脑和想象力的作品：现在是时候，它应该回归对物质和明显事物的观察的朴素和健全了。”胡克的说法在化学领域仍然是正确的，在化学领域，大脑和想象力的大量工作仍然是必要的。原子分辨率的单分子实时透射电子显微镜（SMRT-TEM）成像现在使我们能够通过观看分子的电影来了解分子。就像任何梦想成真一样，新的分析技术挑战了社区的旧常识，并提供了传统方法无法获得的新研究机会。凭借其可视化单个分子和分子簇的运动和反应的能力，SMRT-TEM 技术将成为分子科学、天然和合成物质工程以及科学教育中不可或缺的工具。
“The truth is, the Science of Nature has been already too long made only a work of the Brain and the Fancy: It is now high time that it should return to the plainness and soundness of Observations on material and obvious things,” proudly declared Robert Hooke in his highly successful picture book of microscopic and telescopic images, “Micrographia” in 1665. Hooke’s statement has remained true in chemistry, where a considerable work of the brain and the fancy is still necessary. Single‐molecule, real‐time transmission electron microscope (SMRT‐TEM) imaging at an atomic resolution now allows us to learn about molecules simply by watching movies of them. Like any dream come true, the new analytical technique challenged the old common sense of the communities, and offers new research opportunities that are unavailable by conventional methods. With its capacity to visualize the motions and the reactions of individual molecules and molecular clusters, the SMRT‐TEM technique will become an indispensable tool in molecular science and the engineering of natural and synthetic substances, as well as in science education.