Dendritic cells directly trigger NK cell functions:: Cross-talk relevant in innate anti-tumor immune responses in vivo
Dendritic cells directly trigger NK cell functions:: Cross-talk relevant in innate anti-tumor immune responses in vivo
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DOI：
10.1038/7403
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发表时间：
1999-04-01
期刊：
影响因子：
82.9
通讯作者：
Zitvogel, L
中科院分区：
文献类型：
--
作者：
Fernandez, NC;Lozier, A;Zitvogel, L
细胞毒性T淋巴细胞和自然杀伤细胞是体内抗肿瘤免疫反应的重要效应者。树突状细胞(DC)是肿瘤抗原特异性的细胞毒性T淋巴细胞；因此，我们研究了DC是否也可能触发天然的NK细胞介导的抗肿瘤免疫。在MHC I类阴性肿瘤的小鼠中，过继转移或Flt3配体扩增的DC促进了NK细胞依赖的抗肿瘤效应。体外研究表明，DC和静止的NK细胞之间存在细胞间的接触，导致NK细胞的杀伤活性和干扰素-γ的产生显著增加。因此，DC参与了先天免疫反应和获得性免疫反应之间的相互作用。
Cytotoxic T lymphocytes and natural killer cells are essential effecters of anti-tumor immune responses in vivo. Dendritic cells (DC) 'prime' tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded DC promoted NK cell-dependent anti-tumor effects. In vitro studies demonstrated a cell-to-cell contact between DC and resting NK cells that resulted in a substantial increase in both NK cell cytolytic activity and IFN-gamma production. Thus, DC are involved in the interaction between innate and adaptive immune responses.