Structural characterization of human erythropoietin.
Structural characterization of human erythropoietin.
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发表时间：
1986-03
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通讯作者：
P. Lai;R. Everett;Fung-Fang WangS;T. Arakawa;Eugene GoldwasserS
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作者：
P. Lai;R. Everett;Fung-Fang WangS;T. Arakawa;Eugene GoldwasserS
促红细胞生成素是哺乳动物红细胞形成的主要调节剂。由于其极度稀缺，很少有关于这种重要糖蛋白的结构特征的信息。我们在这里报告的一级结构的人尿促红细胞生成素，蛋白质测序确定。此外，糖基化的网站，分配的二硫键，和圆二色性的激素分析的二级结构与预测的序列相比。
Erythropoietin is the primary regulator of red blood cell formation in mammals. Because of its extreme scarcity, very little information is available regarding structural features of this important glycoprotein. We report here the primary structure of human urinary erythropoietin, determined by protein sequencing. In addition, the sites of glycosylation, assignment of disulfide bonds, and the circular dichroism of the hormone analyzed for secondary structure in comparison with the prediction from the sequence are presented.