Exosomes: New players in cell-cell communication
Exosomes: New players in cell-cell communication
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DOI：
10.1016/j.biocel.2012.08.007
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发表时间：
2012-11-01
影响因子：
4
通讯作者：
Thum, Thomas
中科院分区：
文献类型：
--
作者：
Bang, Claudia;Thum, Thomas
外切体是一种小的膜小泡，由多种类型的细胞分泌。在20世纪80年代，外切体首次被描述为细胞器，用于清除细胞碎片和不需要的分子。外切体含有蛋白质、信使和microRNAs的发现表明，它在细胞间的交流中起到了媒介的作用。外切体可以在不同的细胞之间运输，并影响受体细胞的生理通路。本文就外切体的生物学功能及其在生理和病理过程中的作用作一综述。此外，还将讨论外切体作为生物标志物和治疗工具的潜在临床应用。(C)2012爱思唯尔有限公司。保留所有权利。
Exosomes are small membrane vesicles of endosomal origin, which are secreted from a variety of cell types. During the 1980s exosomes were first described as organelles to remove cell debris and unwanted molecules. The discovery that exosomes contain proteins, messenger and microRNAs suggests a role as mediators in cell-to-cell communication. Exosomes can be transported between different cells and influence physiological pathways in the recipient cells. In the present review, we will summarize the biological function of exosomes and their involvement in physiological and pathological processes. Moreover, the potential clinical application of exosomes as biomarkers and therapeutic tools will be discussed. (C) 2012 Elsevier Ltd. All rights reserved.