Emotion, Cognition, and Behavior
Emotion, Cognition, and Behavior
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DOI：
10.1126/science.291.5508.1449e
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发表时间：
2001-02
期刊：
影响因子：
56.9
通讯作者：
P. Stern
中科院分区：
文献类型：
--
作者：
P. Stern
边缘系统的功能之一是协调情绪和认知。解剖学和生理学研究表明，边缘系统的三个结构--前额叶皮层、杏仁核和脑桥核--是相互连接和相互交流的。杰克逊和莫格汉详细分析了这些区域的相互作用。电刺激杏仁核的基底外侧核增加了前额叶皮层和丘脑核中谷氨酸的释放。与此相反，多巴胺流出量上调，只有在前额叶皮层，而不是在脑桥核。然而，如果前额叶皮层中的多巴胺能神经传递被阻断，那么丘脑核中的多巴胺释放就会随之增加。众所周知，中脑核中的多巴胺能神经传递有助于目标导向行为，这些结果表明，前额叶皮层通过抑制中脑核中的多巴胺释放来调节杏仁核活动的后果。- PRS神经科学杂志。21，676（2001）。
NEUROSCIENCE One of the functions of the limbic system is the coordination of emotion and cognition. Anatomical and physiological studies have shown that three structures of the limbic system—the prefrontal cortex, the amygdala, and the nucleus accumbens—are connected and speak to one another. Jackson and Moghaddam have analyzed the interaction of these areas in detail. Electrical stimulation of the basolateral nucleus of the amygdala increased glutamate release in the prefrontal cortex and in the nucleus accumbens. In contrast, dopamine efflux was upregulated only in the prefrontal cortex and not in the nucleus accumbens. If, however, glutamatergic neurotransmission in the prefrontal cortex was blocked, there was a subsequent increase in dopamine release in the nucleus accumbens. Dopaminergic neurotransmission in the nucleus accumbens is known to contribute to goal-directed behavior, and these results suggest that the prefrontal cortex modulates the consequences of amygdala activity by suppressing dopamine release in the nucleus accumbens. — PRS J. Neurosci. 21 , 676 (2001).