Effect of 8-hydroxy-2-(di-n-propylamino)-tetralin on the tryptophan-induced increase in 5-hydroxytryptophan accumulation in rat brain.
Effect of 8-hydroxy-2-(di-n-propylamino)-tetralin on the tryptophan-induced increase in 5-hydroxytryptophan accumulation in rat brain.
复制标题
8-羟基-2-(二正丙氨基)-四氢萘对色氨酸诱导的大鼠脑中 5-羟基色氨酸积累增加的影响。
DOI：
10.1016/0024-3205(90)90585-f
复制
发表时间：
1990
期刊：
影响因子：
6.1
通讯作者：
Fernstrom,JD
中科院分区：
文献类型：
--
作者：
Fernstrom,MH;Massoudi,MS;Fernstrom,JD
注射8-羟基-2-（二正丙胺基）-四氢萘[8-OH-DPAT]可减少大鼠大脑皮层、下丘脑和脑干中5-羟色氨酸的蓄积。脑色氨酸水平不受影响。通过单次注射L-色氨酸（0、25、75 mg/kg ip）产生的5-羟色氨酸蓄积的剂量相关增加通过8-OH-DPAT预处理显著减少。该药不影响色氨酸诱导的脑色氨酸水平增加。由于已知8-OH-DPAT会降低体内5-羟色胺神经元的活性，因此这些结果表明，当5-羟色胺中子相对不活跃时，注射色氨酸刺激5-羟色胺合成的能力大大减弱。
Abstract The injection of 8-hydroxy-2-(di-n-propylamino)-tetralin [8-OH-DPAT] reduced 5-hydroxytryptophan accumulation in vivo in rat cerebral cortex, hypothalamus and brainstem. Brain trytophan levels were unaffected. Dose-related increases in 5-hydroxytryptophan accumulation produced by single injections of L-tryptophan (0, 25, 75 mg/kg ip) were substantially diminished by pretreatment with 8-OH-DPAT. The drug did not affect the tryptophan-induced increments in brain tryptophan level. Since 8-OH-DPAT is known to reduce the activity of serotonin neurons in vivo, these results suggest that when serotonin neutrons are relatively inactive, the ability of an injection of tryptophan to stimulate serotonin synthesis is greatly attenuated.