Incidence and Prevalence of Crohn's Disease and Ulcerative Colitis in Olmsted County, Minnesota From 1970 Through 2010.
Incidence and Prevalence of Crohn's Disease and Ulcerative Colitis in Olmsted County, Minnesota From 1970 Through 2010.
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DOI：
10.1016/j.cgh.2016.10.039
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Loftus EV Jr
中科院分区：
文献类型：
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作者：
Shivashankar R;Tremaine WJ;Harmsen WS;Loftus EV Jr
炎症性肠病（IBD）的发病率和患病率在全球范围内持续增加。我们试图更新克罗恩病（CD）和溃疡性结肠炎（UC）的发病率在一个明确的美国（US）人口，计算值奥姆斯特德县，明尼苏达州到2010年。我们还计算了患病率值。罗切斯特流行病学项目的资源被用来确定县居民谁被诊断为IBD（CD或UC），根据以前设定的标准。将1970年至2010年期间新诊断为CD或UC的患者确定为发病病例，将2011年1月1日符合诊断标准的患者确定为患病病例。估计了发病率（根据2010年美国白色人群的年龄和性别进行调整）。基于诊断时年龄、性别和诊断年份的发病率趋势通过Poisson回归进行评估。发病队列包括410例CD患者（51%女性）和483例UC患者（56%男性）。CD患者的中位诊断年龄为29.5岁（范围：4-93岁），UC患者为34.9岁（范围：1-91岁）。从2000年至2010年，CD的校正年发病率为10.7例/100，000人-年（95% CI，9.1-12.3人-年），UC为12.2例/100，000人-年（95% CI，10.5-14.0人-年）。2011年1月1日，有380名居民患有CD，调整后的患病率为每10万人246.7例（95%CI，221.7-271.8例/100，000人），435名UC居民，校正患病率为286.3（95% CI，259.1-313.5例/10万人）。男性与UC的高发病率显著相关，年轻与CD的高发病率显著相关。奥姆斯特德县UC和CD的估计发病率是美国最高的。将调整后的患病率外推至最近的美国人口普查，美国可能有约160万IBD患者。
The incidence and prevalence of inflammatory bowel diseases (IBD) continue to increase worldwide. We sought to update incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) in a well-defined United States (US) population, calculating values for Olmsted County, Minnesota through 2010. We also calculated prevalence values. The resources of the Rochester Epidemiology Project were used to identify county residents who were diagnosed with IBD (CD or UC), based on previously set criteria. Those with new diagnoses of CD or UC between 1970 and 2010 were identified as incidence cases, and those meeting diagnostic criteria on January 1, 2011 were identified as prevalence cases. Incidence rates were estimated (adjusted for age and sex to the US white population in 2010). Trends in incidence based on age at diagnosis, sex, and year of diagnosis were evaluated by Poisson regression. The incidence cohort included 410 CD patients (51% female) and 483 individuals with UC (56% male). Median age of diagnosis was 29.5 years for persons with CD (range, 4–93 years) and 34.9 years for UC (range, 1–91 years). From 2000 through 2010, the adjusted annual incidence rate for CD was 10.7 cases per 100,000 person-years (95% CI, 9.1–12.3 person-years) and for UC was 12.2 per 100,000 (95% CI, 10.5–14.0 person-years). On January 1, 2011, there were 380 residents with CD, with an adjusted prevalence of 246.7 cases per 100,000 persons (95% CI, 221.7–271.8 cases per 100,000 persons), and 435 residents with UC, with an adjusted prevalence of 286.3 (95% CI, 259.1–313.5 cases per 100,000 persons). Male sex was significantly associated with a higher incidence rate of UC, and younger age was significantly associated with a higher incidence rate of CD. Estimated incidence rates for UC and CD in Olmsted County are among the highest in the US. Extrapolating the adjusted prevalence to the most recent US Census, there could be approximately 1.6 million persons in the US with IBD.